A BENIGN SYNTHESIS OF 2-AMINO-3-CYANO-4H-BENZOPYRANS VIA DOMINO REACTION
A green and operationally simple approach domino reaction has been developed for the synthesis of 2-amino-3-cyano- 4H-chromene derivatives from aromatic aldehydes, resorcinol and malononitrile in aqueous medium. This work represents the first example of catalyst free and organic solvents free multi-component reactions for the synthesis of pharmaceutically important chromene derivatives. The structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR, IR, Mass and single crystal XRD.
Keywords: Benzopyrans, malononitrile, Michael addition reaction, domino reaction, water mediated synthesis.
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