A BENIGN SYNTHESIS OF 2-AMINO-3-CYANO-4H-BENZOPYRANS VIA DOMINO REACTION
Abstract
A green and operationally simple approach domino reaction has been developed for the synthesis of 2-amino-3-cyano- 4H-chromene derivatives from aromatic aldehydes, resorcinol and malononitrile in aqueous medium. This work represents the first example of catalyst free and organic solvents free multi-component reactions for the synthesis of pharmaceutically important chromene derivatives. The structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR, IR, Mass and single crystal XRD.
Keywords: Benzopyrans, malononitrile, Michael addition reaction, domino reaction, water mediated synthesis.
DOI
https://doi.org/10.22270/jddt.v9i4-A.3417Published
2019-08-30
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SILAMBARASAN SS, Abdul Nasser AJ. A BENIGN SYNTHESIS OF 2-AMINO-3-CYANO-4H-BENZOPYRANS VIA DOMINO REACTION. J. Drug Delivery Ther. [Internet]. 2019 Aug. 30 [cited 2025 Dec. 9];9(4-A):271-9. Available from: https://jddtonline.info/index.php/jddt/article/view/3417
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How to Cite
1.
SILAMBARASAN SS, Abdul Nasser AJ. A BENIGN SYNTHESIS OF 2-AMINO-3-CYANO-4H-BENZOPYRANS VIA DOMINO REACTION. J. Drug Delivery Ther. [Internet]. 2019 Aug. 30 [cited 2025 Dec. 9];9(4-A):271-9. Available from: https://jddtonline.info/index.php/jddt/article/view/3417
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