FORMULATION AND EVALUATION OF MICROSPHERES CONTAINING IMATINIB MESYLATE USING SODIUM ALGINATE BY CHEMICAL CROSS LINKING METHOD
Abstract
The present research deals with formulation of microspheres containing an Anti-cancer drug Imatinib mesylate reduce the side effects and frequency of dosing. It is currently registered and used for two indications, Chronic Myeloid Leukemia (CML) and Gastrointestinal Stromal Tumors (GISTs). Imatinib mesylate loaded microspheres was formulated by using Sodium Alginate polymer by Chemical CrossLinking method to develop a sustained release dosage form. The effect of concentration of polymer ratio on the microspheres properties like percentage of drug loading, biodegradability, drug release kinetics, particle size, encapsulation efficiency, angle of repose, bulk density, SEM, DSC and XRD were investigated in our study. Moreover, the kinetics of Imatinib Meyslate released from different formulations of microspheres were analyzed using four different theoretical models, that is Zero order, First order, Peppa’s and Higuchi models. Microspheres prepared with Glutaraldehyde showed different release kinetics. Increasing the polymer concentration decreased the release rate of Imatinib Meyslate from microspheres because of formation of greater structural strength and more tightly texture with the drug. Besides, microspheres gave an adequate fit to either zero order or first order kinetic models, depending on the extent of cross linking reaction between drug and the cross linking agent.
Key Words: Sodium Alginate, Imatinib Mesylate, microsphere, chemical cross linking, release kinetics.
DOI
https://doi.org/10.22270/jddt.v2i6.339
Published
Abstract Display: 582 
PDF Downloads: 807 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.