Phytochemical Screening and In Vivo Anti-inflammatory Activity of Hydroalcoholic Extract of Embelia Ribes Burm. F
Embelia ribes Burm. f. ( E. ribes, Myrsinaceae), first described by Nicolaas Laurens Burman in 1768, is a woody climber distributed in the primary lowland and mountain forests of Bangladesh, Burma, Cambodia, India, Laos, peninsular Malaysia, Thailand and Vietnam. Ayurvedic medicine prescribes the dried fruits or vidanga and used as antibacterial, antifertility activities, antiprotozoal, abdominal disorders, lung diseases, constipation, indigestion, fungus infections, mouth ulcer, sore throat, pneumonia, heart disease, obesity, analgesic, anti-inflammatory and antioxidant. Inflammation is a reaction of a living vascularised tissue to an injury. Conventional or synthetic drugs used in the treatment of inflammatory diseases are inadequate, it sometimes have serious side effects. So number of herbal medicines is recommended for the treatment of inflammation that has no side effects. The present study is aimed to evaluate the anti inflammatory activity of E. ribes on formalin induced paw edema in rats as for controlling inflammatory disorders. Acute toxicity of the extract (2000 mg/kg) was examined in wistar rats for 14 days. Qualitative analysis of various phytochemical constituents and quantitative analysis of total phenolics and flavonoids were determined by the well-known test protocol available in the literature. Phytochemical analysis revealed the presence of phenols, flavonoids, tannins, saponins, alkaloids ect. The total phenolics content of E. ribes extract was (1.155mg/100mg), followed by flavonoids (0.811mg/100mg) respectively. Hydroalcoholic extract up to 2000 mg/kg did not produce any toxic effects. The hydroalcoholic extract of E. ribes (100 and 200 mg/kg) inhibited the inflammation induced by formalin in rats in a dose dependent manner. The results of present study demonstrate that hydroalcoholic extract of the seeds of E. ribes possess significant (P < 0.05) anti-inflammatory potential.
Keywords: Embelia ribes Burm. f, Acute toxicity, Anti-inflammatory effect, Phytochemical screening, Flavonoid, paw edema
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