Synthesis and Biological Evaluation of Some Piperazine Derivatives as Anti-Inflammatory Agents

Authors

  • Nalini Patel
  • Vaishali Karkhanis
  • Pinkal Patel

Abstract

Some 1-((4-methylpiperazin-1yl)methyl)-1H-benzo[d]imidazole & 1-((4-phenylpiperazin-1yl)methyl)-1H-benzo[d]imidazole derivatives were synthesized through reaction of 1-substituted piperazines with different benzimidazole derivatives in methanol yielded the corresponding mannich bases (42-a to 42-i). All the synthesized compounds were elucidated by IR, 1H NMR and MASS spectroscopy. They were tested for anti-inflammatory activity using in-vivo (Carrageenan- induced rat paw edema model) method at a dose of 50mg/kg. result showed that compounds 42-c, 42-d and 42-h were found to be most potent in series.

Keywords: 1,4-disubstituted Piperazine, Anti-inflammatory, Mannich Base.

DOI

https://doi.org/10.22270/jddt.v9i4-s.3327

Published

15-08-2019
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How to Cite

1.
Patel N, Karkhanis V, Patel P. Synthesis and Biological Evaluation of Some Piperazine Derivatives as Anti-Inflammatory Agents. J. Drug Delivery Ther. [Internet]. 2019 Aug. 15 [cited 2025 Feb. 12];9(4-s):353-8. Available from: https://jddtonline.info/index.php/jddt/article/view/3327

How to Cite

1.
Patel N, Karkhanis V, Patel P. Synthesis and Biological Evaluation of Some Piperazine Derivatives as Anti-Inflammatory Agents. J. Drug Delivery Ther. [Internet]. 2019 Aug. 15 [cited 2025 Feb. 12];9(4-s):353-8. Available from: https://jddtonline.info/index.php/jddt/article/view/3327