In-Vitro Anti-Fungal Activity and Phytochemical Screening of Stem Bark Extracts from Ventilago denticulata

  • NV Devhadrao
  • AS Bansode
  • VS Shende
  • SH Thokal
  • SS Bhalerao
  • PB Bhalerao
  • OL Dhage
  • AB Tambe

Abstract

The objective of the present study was to assess the antifungal activity of pet. Ether extract, acetone extract, ethyl acetate, and ethanol bark extract of Ventilago denticulata (VD).The material was dried in shade made to a coarse powder and weighted quantity of the powder   (1000 g) was subjected to hot percolation in a soxhlet apparatus using petroleum ether, ethyl acetate, acetone and ethanol, at a temperature range of 40-800C. Phytochemical tests were done in presence of phytoconstituents like glycosides, alkaloids, tannins, steroids, flavonoids. The anti-fungal activity was carried out by using cup method using Sabraud’s agar as medium. Plates were incubated at 250C for 42hr and later observed for zones of inhibition. The effect of the extracts on fungal isolates was compared with Griseofluvin at a concentration of 10 mg/ml. The Ethyl acetate extract at low as well as high doses gives antifungal effect. Pet-ether extract, acetone extract and ethanolic extract did not produce any antifungal effect at both doses. Ethyl acetate extract shows zone of inhibition at low dose (T1 10 mg/ml) 10 mm and at high dose (T20 mg/ml) 16 mm.


Keyword: Ventilago denticulata, Anti- fungal, Griseofluvin.

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Devhadrao N, Bansode A, Shende V, Thokal S, Bhalerao S, Bhalerao P, Dhage O, Tambe A. In-Vitro Anti-Fungal Activity and Phytochemical Screening of Stem Bark Extracts from Ventilago denticulata. JDDT [Internet]. 15Aug.2019 [cited 14Jun.2021];9(4-s):359-62. Available from: https://jddtonline.info/index.php/jddt/article/view/3326