Design Formulation and Evaluation of Soluble Soft Gel Ocular Insert of Ketorolac Tromethamine using Modified Locust Bean Gum

Abstract

A  major  problem   in   ocular  therapeutics   is   the  attainment   of  optimal   drug concentration at the site of action which is compromised mainly due to precorneal      loss  resulting in  only a  small  fraction  of the drug being ocularly absorbed.  The effective dose administered may be altered by increasing the retention time of medication into the eye by using ocular inserts for treating various ocular diseases. The aim of the present study was to prepare and evaluate novel Ocular inserts of Ketorolac Tromethamine with polymers like HPMC K4M, PVA, Locust Bean Gum and Modified Locust Bean Gum with Glycerol as plasticizer by film casting method. Nine formulations of ocular inserts based on Comaprision Study On the basis of In vitro release studies & physicochemical parameters, the formulation MOG sustained with maximum cumulative of 97.244% for a period 12 hr and it was found to be better than other formulations; hence MOG 2% was selected as optimized formulation. In vitro drug release kinetic data revealed that all formulation followed near to zero order release kinetics, involving in the all formulation drug release by Super Case-II type of diffusion. Optimized formulation (MOG 12%) passed the test for sterility and in stability studies no change of physiological properties.  On the basis  of the present  study,  the ocular  inserts  of Ketorolac Tromethamine  gives  promising  future  for  the  ophthalmic  drug  delivery system.

Keywords: Ketorolac Tromethamine, Ocular inserts, HPMC K4M, PVA, LBG, MOG