FORMULATION AND EVALUATION OF NANOEMULSION FOR TOPICAL APPLICATION

FORMULATION AND EVALUATION OF NANOEMULSION FOR TOPICAL APPLICATION

Authors

  • Neha M Shaikh
  • S. M. Vijayendra Swamy
  • NAGOBA SHIVAPPA NARSING Channabasweshwar Pharmacy College, Kava Road, Latur-413512, Dist. Latur. (MS)
  • K B Kulkarni

Abstract

The aim of present research is to design and develop nanoemulsion of Econazole nitrate as effective treatment for tinea versicolor fungal disease. Econazole nitrate is an imidazole antifungal agent with broad spectrum activity. It belongs to BCS class II i.e. low soluble and highly permeable drug. Due to its poor solubility, it is incompletely absorbed after oral dosing and bioavailability varies among individuals. The drug efficacy of topical formulation can be limited by instability due to its poor solubility in the vehicle and low permeability. Therefore, to overcome these problems nanoemulsions have been designed. Topical nanoemulsion containing 1 % Econazole nitrate with different oils (oleic acid), surfactant (tween 20), co-surfactant (PEG 200, PEG 400) and distilled water. Various oil-in-water nanoemulsions are prepared by the spontaneous emulsification method. The nanoemulsion formulations that passed thermodynamic stability tests were characterized for appearance, pH, FTIR, viscosity, drug content, % drug entrapment efficiency and in-vitro drug release study of Econazole nitrate determined by Franz diffusion cell and stability study.

DOI

https://doi.org/10.22270/jddt.v9i4-s.3301

Published

15-08-2019
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How to Cite

1.
Shaikh NM, Vijayendra Swamy SM, NARSING NS, Kulkarni KB. FORMULATION AND EVALUATION OF NANOEMULSION FOR TOPICAL APPLICATION: FORMULATION AND EVALUATION OF NANOEMULSION FOR TOPICAL APPLICATION. J. Drug Delivery Ther. [Internet]. 2019 Aug. 15 [cited 2025 Feb. 15];9(4-s):370-5. Available from: https://jddtonline.info/index.php/jddt/article/view/3301

How to Cite

1.
Shaikh NM, Vijayendra Swamy SM, NARSING NS, Kulkarni KB. FORMULATION AND EVALUATION OF NANOEMULSION FOR TOPICAL APPLICATION: FORMULATION AND EVALUATION OF NANOEMULSION FOR TOPICAL APPLICATION. J. Drug Delivery Ther. [Internet]. 2019 Aug. 15 [cited 2025 Feb. 15];9(4-s):370-5. Available from: https://jddtonline.info/index.php/jddt/article/view/3301