Development and evaluation of Zotepine loaded mucoadhesive microemulsion for intranasal delivery
Abstract
Mania and bipolar illness are the major problems in the schizophrenia treatment, zotepine, atypical antipsychotic drug used for this condition. The aim of present investigation was to develop mucoadhesive microemulsion of zotepine for intranasal delivery by phase titration method. The developed formulations were evaluated for its size, zeta, PDI and invitro release studied. The optimized formulation, containing 5% Oleic acid, 40% Tween 80: PEG400 (3:1) and 55% water. The globule size (53.1±0.31), zeta potential (-32.1±0.2),PDI (0.13±0.23).0.5% chitosan was added to the optimized formulation to prepare mucoadhesive formulation.
Keywords: Zotepine; Microemulsion; pseudoternary phase diagram; solubility;
DOI
https://doi.org/10.22270/jddt.v9i4-s.3244References
Schizophrenia, National Institute of Mental Health, Available from: http://www.nimh.nih.gov/health/topics/schizophrenia/index.shtml.
Anilgoud K, Anjali Devi N. Formulation and Characterization of Quetiapine Fumarate loaded mucoadhesive microemulsion for intranasal delivery, World Journal of Pharmaceutical and Medical Research ,4(9),176-180, (2018)
Factor SA. Pharmacology of atypical antipsychotics. Clinical neuropharmacology. 2002 May 1;25(3):153-7.
Green B. Zotepine: a clinical review. Expert opinion on drug metabolism & toxicology. 2009 Feb 1;5(2):181-6.
Löscher W, Potschka H. Blood-brain barrier active efflux transporters: ATP-binding cassette gene family. NeuroRx. 2005 Jan 1;2(1):86-98.
Popescu C, Manda P, Juluri A, Janga KY, Cidda M, Murthy SN. Enhanced dissolution efficiency of zaleplon solid dispersions via modified β-cyclodextrin molecular inclusion complexes. J. Pharm Pharm Scien. 2015;1(1):12-21.
Nasrallah HA, Targum SD, Tandon R, McCombs JS, Ross R. Defining and measuring clinical effectiveness in the treatment of schizophrenia. Psychiatric Services. 2005 Mar;56(3):273-82.
Vyas TK, Babbar AK, Sharma RK, Singh S, Misra A. Intranasal mucoadhesive microemulsions of clonazepam: preliminary studies on brain targeting. Journal of pharmaceutical sciences. 2006 Mar 1;95(3):570-80.
Li L, Nandi I, Kim KH. Development of an ethyl laurate-based microemulsion for rapid-onset intranasal delivery of diazepam. International journal of pharmaceutics. 2002 Apr 26;237(1-2):77-85.
Kaur P, Kim K. Pharmacokinetics and brain uptake of diazepam after intravenous and intranasal administration in rats and rabbits. International journal of pharmaceutics. 2008 Nov 19; 364(1):27-35.
Jogani VV, Shah PJ, Mishra P, Mishra AK, Misra AR. Intranasal mucoadhesive microemulsion of tacrine to improve brain targeting. Alzheimer Disease & Associated Disorders. 2008 Apr 1;22(2):116-24.
Porecha S, Shah T, Jogani V, Naik S, Misra A. Microemulsion based intranasal delivery system for treatment of insomnia. Drug delivery. 2009 Apr 1;16(3):128-34.
Shah BM, Misra M, Shishoo CJ, Padh H. Nose to brain microemulsion-based drug delivery system of rivastigmine: formulation and ex-vivo characterization. Drug delivery. 2015 Oct 3;22(7):918-30.
Hu L, Wu H, Niu F, Yan C, Yang X, Jia Y. Design of fenofibrate microemulsion for improved bioavailability. International journal of pharmaceutics. 2011 Nov 28;420(2):251-5.
Chandra A, Sharma PK, Irchhiaya R. Microemulsion-based hydrogel formulation for transdermal delivery of dexamethasone. Asian Journal of Pharmaceutics (AJP): Free full text articles from Asian J Pharm. 2014 Aug 28;3(1).
Anjali Devi N, Krishnaveni J. Development and Ex-Vivo evaluation of atorvastatin microemulsions for transdermal delivery using Box-Behnken Design. International Journal of Pharmacy and Biological Sciences, 2018,8 (2): 81-93.
Kawtikwar PS, Kulkarni NP, Yadav S, Sakarkar DM. Formulation and evaluation of an anti-epileptic drug-loaded microemulsion for nose to brain delivery. Asian Journal of Pharmaceutics (AJP): Free full text articles from Asian J Pharm. 2014 Aug 28;3(2).
Hintzen F, Perera G, Hauptstein S, Müller C, Laffleur F, Bernkop-Schnürch A. In vivo evaluation of an oral self-microemulsifying drug delivery system (SMEDDS) for leuprorelin. International journal of pharmaceutics. 2014 Sep 10;472(1-2):20-6.
Anilgoud K, Krishnaveni J and. "Development and Ex vivo evaluation of Rasagiline Mesylate mucoadhesive microemulsion for intranasal delivery using Box-Behnken design." International Journal of Bio-Pharma Research 2019 8(3): 2514-2522.
Published
Abstract Display: 691 
PDF Downloads: 734 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.