FORMULATION AND EVALUATION OF LIQUISOLID COMPACTS OF OLANZAPINE

Abstract

The Main objective of the present study was to enhance the dissolution rate of olanzapine by liquisolid compact method. Olanzapine is practically insoluble in water. Solubility of olanzapine was estimated in different nonvolatile solvents. The study was designed to evaluate the effect of various formulation parameters like Drug concentration and Excipient ratio on angle of repose and % drug release using 3²  full factorial design. Quality control tests were done to evaluate each batch of tablets.  Liquisolid compact powder was subjected to angle of repose, Carr’s index, and hausner’s ratio to determine flow property. Hardness, friability, disintegration time, drug content, dissolution rate are determined. Fourier transforms infrared analysis, x-ray diffraction studies also performed. All the formulations showed acceptable flow property and better drug release. The optimized batch was subjected to stability studies for 30 days. The dissolution profile of optimized batch was compared with direct compressed tablet and with marketed preparation. Fourier transform infrared spectroscopy conformed that drug does not interact with excipients which are added in the formulation. X-ray diffraction study proved that olanzapine (crystalline form) converted into amorphous form. From this study it was concluded that liquisolid compact technique improves dissolution rate of olanzapine.