Formulation and Evaluation of Traditional Antioxidant Grape Seeds Extract in the Form of Tablets

Abstract

Oxygen uptake while breathing cause’s free radical production and in addition to that environmental factors such as pollutants, smoke and certain chemicals also contribute to their formation. Reactive oxygen species is a collective term that includes all reactive forms of oxygen, including both oxygen radicals and several non-radical oxidizing agents that participate in the initiation and/or propagation of chain reaction. Free radicals are atoms, molecules or ions with unpaired electrons that are highly unstable and active towards chemical reactions with other molecules. Antioxidant is any substance that when present at low concentrations compared to those of an oxidizable substrate significantly delays or prevents oxidation of that substrate. Antioxidants block the process of oxidation by neutralizing free radicals. Antioxidant power of proanthocyanidins is 20 times greater than vitamin E and 50 times greater than vitamin C. Proanthocyanidins in Grape seeds have been shown to exhibit strong antioxidant, antimutagenic, anti-inflammatory, anticarcinogenic and antiviral activity.

Keywords- Antioxidants, Grape seed, Proanthocyanidins, DPPH activity.