LACTOFERRIN, A PROMISING MOLECULE FOR THE TREATMENT OF ANEMIA OF CHRONIC KIDNEY DISEASE.
Commonly available therapeutic approaches for treating anemia of chronic kidney disease include oral iron supplementation such as ferrous fumarate, intra venous iron administration and erythropoiesis stimulating agents including erythropoietin, darbepoetin alfa, etc. Nowadays ESAs are used widely to treat anemia of chronic kidney disease and several studies have found that if used inappropriately it can even lead to cardiovascular diseases. The harmful effect of free iron in human body includes microbial growth promotion and free radical-induced reactions which can further cause deterioration of patient condition. Iron overload can lead to organ multiple organ failure in kidney disease patients. The iron level in the body is one of the significant factor for the effectiveness of erythropoietin. A well maintained iron homeostasis is required in the kidney disease patients to observe an effective treatment for anemia in chronic kidney disease patients. Lactoferrin, an iron-binding glycoprotein has been studied widely for its effect on iron homeostasis, anti-microbial activity, etc. Its safety and efficacy over other oral iron supplements have been established from several studies. This review article aims to support the need for further studies for attaining more vast knowledge regarding the use of lactoferrin in the treatment of anemia of chronic kidney disease.
Keywords: Anemia in chronic kidney disease, free iron, erythropoiesis stimulating agents (ESA), Lactoferrin, Glycoprotein, Iron homeostasis
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