APPROACH OF CO-MICRONIZATION IN SOLUBILITY ENHANCEMENT AND RELEASE PROFILE OF RAPID DISPERSIBLE TABLETS OF TOLFENAMIC ACID
Abstract
Tolfenamic Acid is an orally and parenterally administered Non – steroidal anti-inflammatory drug belonging to the fenamate group. Dissolution is the rate limiting step for the absorption of Tolfenamic acid due to its poor solubility. In order to improve the solubility of drug and its dissolution rate concept of co-micronization of Tolfenamic acid with diluents and surfactants was studied in present study. Tolfenamic acid was co-micronized with microcrystalline cellulose and surfactants as sodium Lauryl sulfate. One reference formulation was also manufactured with conventional method using non-micronized Tolfenamic acid with surfactants. The formulation was than evaluated for various physical and analytical properties of rapid dispersible tablets. Results obtained showed that there was a significant increase in dissolution rate of drug in first 5 minutes of time interval as compare to reference formulation. The wetting and dispersion properties of formulation also found superior as compare to reference formulation.
DOI
https://doi.org/10.22270/jddt.v2i6.317
Published
Abstract Display: 553 
PDF Downloads: 1523 PDF Downloads: 0 PDF Downloads: 0 PDF Downloads: 0 PDF Downloads: 0 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.