PULSATILE DRUG DELIVERY AS MODIFIED RELEASE DOSAGE FORM : A REVIEW

Abstract

Pulsatile drug delivery is a advanced drug delivery system in pharmaceutical field . Pulsatile system is one of the modified release dosage form system and gaining a lot of interest as it is increasing patient compliance by means of providing time- and site-specific drug delivery system. Pulsed or pulsatile drug release is defined as the rapid and transient release of a certain amount of drug molecules within a short time-period immediately after a predetermined off-release period. In various diseases in which we can recomend the pulsatile drug delivery system such as duodenal ulcer, cardiovascular diseases, arthritis, asthma, diabetes, neurological disorder, cancer, hypertension and hypercholesterolemia. This article summarize the various methodologies, evaluation parameters and compile the recent literatures with special focus on the different types and approaches involved in the development of the formulation