A Review on Formulation and Evaluation of Sustained Release Tablet of Devilproex Sodium
An appropriately designed drug delivery system can be a major step towards solving these two problems. This technique for the drug administration is termed as ‘sustained release’ or ‘controlled release. Drugs with dosage not exceeding 125mg – 325mg are more suited as extended release products in order to limit the size of the delivery system. In the case of soluble matrix the matrix swells or dissolves. These matrices then undergo surface erosion with little or no bulk erosion. Divalproex sodium dissociates to the valproate ion in the gastrointestinal tract. The mechanisms by which valproate exerts its therapeutic effects have not been established. One of its most important characteristics is the high gelation velocity and viscosity, which has a significant effect on the release kinetics of the incorporated drug. It was proven that HPMC at high concentration promoted the drug release approaching to a zero-order release kinetic because of its gelation properties
Keywords: HPMC, Divalproex sodium, sustained release and zero-order release kinetic
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