Development of Micro-Emulsion Gel Based Topical Delivery of Salicylic Acid and Neem Oil for the Management of Psoriasis
Abstract
Microemulsions (MEs) are clear, thermodynamically stable systems. They were used to solubilise drugs and to improve topical drug availability. Salicylic acid (SA) is a keratolytic agent used in topical products with antimicrobial actions. This study aimed to formulate an optimized SA micro emulsion gel for the slow, variable and incomplete oral drug absorption in patient suffering from psoriasis infection. The dispersion solubility of SA was studied in various oils, surfactants and co-surfactants and by constructing pseudo phase ternary diagram, micro emulsion area was identified. The optimized formulations of micro emulsion were subjected to thermodynamic stability tests. After stability study, stable formulation was characterized for droplet size, pH determination, centrifugation, % drug content in micro emulsion, zeta Potential and vesicle size measurement and then micro emulsion gel were prepared and characterized for spreadability, measurement of viscosity, drug content, In-vitro diffusion, in-vitro release data. Labrasol was selected as surfactant, plurol oleique as co surfactant and neem oil as oil component based on solubility study. The optimized formulation contained SA 0.05 (%w/w), labrasol (24%), plurol oleique (8 %) and neem oil (8%). The in vitro drug release from SA micro emulsion gel was found to be considerably higher in comparison to that of the pure drug. The in-vitro diffusion of micro emulsion gel was significantly good. Based on this study, it can be concluded the solubility and permeability of SA can be increased by formulating into micro emulsion gel.
Keywords: Salicylic Acid, Neem Oil, Micro-emulsion, In-vitro diffusion, Zeta potential, Stability, Labrasol
DOI
https://doi.org/10.22270/jddt.v9i4.3023References
Schon MP, Boehncke WH. Psoriasis. New England Journal of Medicine 2005; 352(18):1899-1912.
Glickman FS. Lepra, psora, psoriasis. Journal of the American Academy of Dermatology1986; 14:863-6.
Lo KK, Ho LY. Psoriasis In: Handbook of Dermatology and Venereology. HongKong: Social Hygiene Service, Department of Health. 1997.
Liu Y, Krueger JG, Bowcock AM. Psoriasis: genetic associations and immune system changes. Genes and immunity 2007; 8(1):1-2.
Boehncke WH, Schon MP. Psoriasis. Lancet 2015; 5:983-94.
Collier K, Matalonis S, Owen AJ. Evaluation of permeability enhancement by microemulsion in a caco-2 cell system. Proc Int Symp Control Release Bioact Mater. 1999; 26:5444-9.
Alany RG, Rades T, Agatonovic-Kustrin S, Dvies NM, Tucker IG. Effects of alcohols and diols on the phase behaviour of quaternary systems. Int J Pharm. 2000; 196:141-5.
Trotta M, Pattarino F, Grosa G. Formation of lecithin-based microemulsions containing n-alkanol phosphocholines. Int J Pharm. 1998; 174:253-9.
Marti-MestresG, Nielloud F. Emulsions in health care applications- an overview. J Dispers Sci Technol. 2002; 23:419-39.
Osborne DW, Ward AJ, O’Neill KJ. Microemulsions as topical drug delivery vehicles: in-vitro transdermal studies of a model hydrophilic drug. J Pharm Pharmacol Comm. 1991; 43:451-4.
Jachowicz J, Berthiaume MD. Microemulsions vs. macroemulsions in hair care products. Cosmet Toiletries. 1993; 108:65-72.
Orth DS, Widjaja J, Ly L, Cao N, Shapiro WB. Stability and skin persistence of topical products: evaluating the effect of a hydroalcoholichydroquinone vehicle. Cosmet Toiletries 1998; 113 (10):51-63.
Reynolds JEF, editor. Martindale, the extra pharmacopoeia, 30th edition. London: The Pharmaceutical Press; 1993.
Bashir SJ, Dreher F, Chew AL, Zhai H, Levin C, Stern R, et al. Cutaneous bioassay of salicylic acid as a keratolytic. Int J Pharm. 2005; 292:187-94.
Park WB, Kim SH, Cho JH, Bang JH, Kim HB, Kim NJ, et al. Effect of salicylic acid on invasion of human vascular endothelial cells by Staphylococcus aureus. FEMS Immunol Med Microbiol. 2007; 49:56-61.
Kupferwasser LI, Yeaman MR, Nast CC, Kupferwasser D, Xiong YQ, Palma M, et al. Salicylic acid attenuates virulence in endovascular infections by targeting global regulatory pathways in Staphylococcus aureus. J Clin Invest. 2003; 112(2):222-33.
British Medical Association and the Royal Pharmaceutical Society of Great Britain. British National Formulary, No. 26; 1993. p. 408-10.
Patel MR, Patel RB, Parikh JR, Solanki AB, Patel BG. Effect of formulation components on the in vitro permeation of microemulsion drug delivery system of fluconazole. AAPS PharmSciTech. 2009; 10: 917-923.
Patel MR, Patel RB, Parikh JR, Solanki AB. Investigation of efficiency of isopropyl myristate-based oil in water microemulsions for topical delivery of fluconazole. Int Biomed Phann Sci. 2009; 3: 60-68.
Djordjevic L, Primorac M, Stupar M, Krasjinik D. Characterization of caprylocaproyi macrogolglycerides based microemulsion drug delivery vehicles for an amphiphilic drug. Int J Pharm. 2004; 271:11-19.
Li L, Nandi I, Kim KH. Development of an ethyl laurate-based microemulsion for rapid-onset intranasal delivery of diazepam. Int J Pharm. 2002; 237: 77-85.
Ghosh PK, Majithiya RJ, Umrethia ML, Murth RSR. Design and development of microemulsion drug delivery system of acyclovir for improvement of oral bioavailability. AAPS Pharm Sci Tech. 2006; 7 (3):Article 77.
Ghosh PK, Majithiya RJ, Umrethia ML, Murth RSR. Preparation and characterization of caprylocapryl macrogol -8- glycerides microemulsion for pral drug delivery. Ars Pharm. 2004; 45(3):353-372.
Zhu W, Aihua YU, Wang W, Dong R, Wu J. Formulation design of microemulsion for dermal delivery of penciclovir. Int J Pharm. 2008; 360:184-190.
Biruss B, Valenta C. Skin permeation of different steroid hormones from polymeric coated liposomal formulations. Eur J Pharm Biopharm. 2006; 62: 210-219.
Biruss B, Valenta C. The advantage of polymer addition to a non-ionic ails in water microemulsion for the dermal delivery of progesterone. Int J Pharm. 2008; 349: 269-273.
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