Putative Role of Moringa oleifera in Prophylaxis of Chemotherapy Induced Neuropathic Pain in Mice
Abstract
Cancer chemotherapy is associated with a plethora of morbidities among which neuropathic pain is a prevalent one. The pathology underpinning chemotherapy induced neuropathic pain can be multifarious, however, dearth of effective medication largely plagues the quality of life of such patients. A good rationale can be found behind focusing on herbal alternatives like extracts of Moringa oleifera for which anti-cancer potential has already been reported. Hence we have carried out a pilot study for evaluating the protective potential of the methanolic extract of the plant against paclitaxel induced neuropathic pain in mice. Our evaluation has been based on standard paradigms focusing on neuromotor, oxidative and histopathological assessments. We have found significant improvisation in groups treated with both pregabalin and extract, the amelioration being largely graded in nature. Hence our research has opened up the doors of a newer horizon of herbal alternatives available for chemotherapy induced neuropathic pain, however further look out into the domain is avidly awaited for.
Keywords: NP: Neuropathic Pain, CC: Cancer Chemotherapy, HA: Herbal Alternatives
DOI
https://doi.org/10.22270/jddt.v9i3-s.2924References
Guido Cavaletti , Paola Alberti , Barbara Frigeni , Marialusia Piatti , Emanuela Susani ; Chemotherapy Induced Neuropathic Pain ; Cuurent Treatment Options in Neurology (2011)13:180 -190
Hau Jung Park ; Chemotherapy induced peripheral neuropathic pain ; Korean Journal of Anesthesiol ,2014 July 67(1) :4-7
R Gupta , A Bhaskar ; Chemotherapy – induced peripheral neuropathic pain in mice ; BJA Education , Volume 16 , No :4 , April 2016
Nicolas Tsavaris , Petros Kopterides , Christos Kosmas , Athina Efthymiou , Hlias Skopelitis , Antonios Dimitrakopoulos , Eyterpi Pagouni , Dimitrios Pikazis , Panagiotis –Vasilis Zis , Christos Koufos ; Gabapentin Monotherapy for the treatment of chemotherapy induced neuropathic pain : A pilot study; American Academy of Pain Medicine , 2008 , Volume :9 , Number :8 , Page no : 1209-1216
Mark J. Lema , Kathleen M. Foley , Frederick H. Hausheer ; Types and Epidemiology of Cancer –Related Neuropathic Pain : The Intersection of Cancer Pain and Neuropathic Pain ; The Oncologist 2010;15 , Page no : 3-8
Shrikant Atreya ; Pregabalin in chemotherapy induced neuropathic pain ; Indian Journal of Palliative Care , 2016 , Volume :22 , No : 1 , Page no 101 – 103
M .T . Fallon ; Neuropathic pain in cancer ; British Journal of Anaesthesia 111 (1) : 105 -11 (2013)
V Loomba , H Kaveeshvar , A Upadhyay , N Sibai ; Neuropathic pain in cancer patients : A brief review ; Indian Journal of Cancer , 2015 , Volume : 52 , No : 3 , Page no : 425 -428
Renata Zajaczkowska , Magdalena Kocot Kepska , Wojciech Leppert , Anna Wrzosek , Joanna Mika , Jerzy Wordliczek ; Mechanisms of Chemotherapy - Induced Peripheral Neuropathy ; International Journal of Molecular Sciences. 2019 , 20(6) , 1451 -1459
Wang X , Shen X , Xu Y Xu S , Xia F , Zhu B , Liu Y , Wang W, Wu H , Wang F; The etiological changes of acetylation in peripheral nerve injury – induced neuropathic hypersensitivity ; Molecular Pain , Volume 14: 1-9
Brandolini Laura , Benedetti Elisabetta , Ruffini Pier Adelchi , Russo Roberto , Cristiano Loredana , Antonosante Andrea ,d’ Angelo Michele , Castelli Vanessa , Giordano Antonio , Allegretti Marcello , Cimmi Annamaria ; CXCR1 /2 pathways in paclitaxel – induced neuropathic pain ; Oncotarget , 2017 , Vol .8 (No .14), PP: 23188 – 23201
Lisa A. Griffiths, Natalie A. Duggett , Ann L. Pitcher , Sarah J.L . Flatters; Evoked and Ongoing Pain – Like Behaviours in a Rat Model of Paclitaxel –Induced Peripheral Neuropathy; Pain Research and Management;2018, Volume 17.
Guilia Donvito , Jenny L. Wilkerson , M. Imad Damaj , Aron H. Lichtman ; Palmitoyethanolamide Reverses Paclitaxel – Induced Allodynia in Mice ; The Journal of Pharmacology and Experimental Therapeutics 359 : 310 -318 , November 2016
Published
Abstract Display: 638 
PDF Downloads: 613 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.