Synthesis, Characterization and Drug delivery of Verapamil Hydrochloride loaded Montmorillonite Nanocomposite Beads
Abstract
In the present research programme, Verapamil Hydrochloride loaded Sodium Alginate/Polyethylene oxide/Montmorillonite nanocomposite beads were prepared by using gelation method. Sodium alginate (SA) and Poly ethylene oxide (PEO) with different ratios were blended with different weight ratios of MMT solution. The nanocomposite beads were characterized Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscope (SEM), X-ray diffraction (X-RD). FTIR was used to understand the hydrogen bonding between SA, PEO, MMT and drug. The X-RD studies were performed to understand the crystalline nature of drug after encapsulation into the beads. SEM was used to study the surface morphology of nanocomposite beads. In vitro studies were carried out in buffer media by using UV-vis spectroscopy(λmax-263nm) at pH 7.4. The Controlled drug release studies were observed upto 12hrs.
Keywords: Sodium Alginate (SA), Poly ethylene oxide (PEO), Montmorillonite (MMT), Verapamil Hydrochloride (VPHCl), Nanocomposite beads and Drug Delivery
DOI
https://doi.org/10.22270/jddt.v9i3-s.2876Published
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