Liquid Filled Hard Gelatin Capsule
Abstract
Novel dosage forms emerges more and more in recent years. One of them is liquid-filled hard gelatin capsules, which have gelatin or the hydroxypropyl methyl cellulose (HPMC) as capsule shell. The liquid-filled hard gelatin capsule is gradually getting attention because of its new-concept dosage form design, which bring liquid drugs by solid form. The paper mostly presents application, pharmaceutical manufacturing, quality assessment, vision of liquid-filled hard gelatin capsules and emphases on the application and pharmaceutical manufacturing of liquid-filled capsule. It is recommended that the capsule is suitable for many liquid or semi-solid natural plant extract and achieve different release profiles. The preparation adopted liquid-filled hard capsules technology. The impact factors concluded property of shell and device of filling. The quality was frequently evaluated by moisture content of capsule shell, dissolution rate. At the same time, it was pointed out that the new dosage form has remarkable marketing prospect and bring profits for enterprises.
Keywords: Liquid filled capsule, Capsule Shell, Gelatin, HPMC, Dissolution rate.
DOI
https://doi.org/10.22270/jddt.v9i3-s.2794References
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