Formulation and evaluation fast dissolving tablets of lovastatin using solid dispersion method
Abstract
The research worked based using solid dispersion method though poorly soluble drugs lovastatin formulating it as solid dispersions subsequent preparation of fast dissolving tablets with the prepared solid dispersions using different concentrations of super disintegrates and comparing them with that of the marketed product. Lovastatin is a HMG CoA reductase inhibitor used in the treatment of hyperlipidemias and prevention of ischemic heart disease. It is practically insoluble in water, sparingly soluble in alcohol and soluble in acetone. In the present investigation lovastatin and solid dispersion were prepared by physical mixing, fusion, solvent evaporation and lyophilizafion methods using polyethylene glycol-6000 as an inert amphiphilc carrier. The prepared solid dispersions were evaluated for pre compressional parameters such as angle of repose, Carr’s index, particle size and drug content.
Keywords: solid dispersion, poorly soluble drugs, super disintegrates.
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