Histopathological changes in the rat liver and kidney with references to nicotine toxicity
Abstract
Nicotine, the principal alkaloid in tobacco, induces a cellular damage on heart and cardiomyocyte culture. The present study was undertaken to investigate the effects of green tea and guduchi extracts on nicotine-induced alterations in some organs of adult male mice (liver and kidney) by using histopathological studies. A total of 36 mice were divided into six groups For histopathological studies. Liver and kidney were excised from both control and experimental mice sacrificed on 60th day. Statistical analysis was performed for comparison between the groups by using Dunnett’s test. There was decreased inflammatory infiltration and intracellular edema in histology of renal tissue from green tea and guduchi extracts treated mice reflected a reduction in nicotine-induced renal damage. The histopathological examination of liver clearly revealed that the Hepatic Cells, Intact nucleus, and Central Vein, portal triad were almost normal in other groups in contrast to group which received inducer but with mild Kupffer cell hyperplasia.The results of present work suggested that green tea and guduchi extracts has a promising prophylactic effect against nicotine-induced oxidative damage of liver and kidney.
Keywords: Green tea, Guduchi extracts, Histopathology, Liver, Kidney, Toxicity, Mice.
DOI
https://doi.org/10.22270/jddt.v9i3.2701References
Tutka P., Mosiewicz J., Wielosz M.:Pharmacol. Rep. 2005; 57:143.
Erat M., Ciftci M., Gumustekin K., Gul M.: Eur. J. Pharmacol. 2007; 554:92.
Neogy S., Das S., Mahapatra S.K., Mandal N.,Roy S.: Environ. Toxicol. Pharm. 2008; 25:321.
Hu N., Guo R., Han X.: Toxicol. Lett. 2011; 202:8.
Hu D., Cao K., Wakemann R P., Wang R.: Biochem. Biophys. Res. 2002; 297:729.
Zhou X., Sheng Y., Yang R., Kong X.: Cardiology 2010; 115:243.
Boehm K, Borrelli F, Ernst E, Habacher G, Hung SK, Milazzo S, Horneber M. Green tea (Camellia sinensis) for the prevention of cancer. Cochrane Database Syst Rev. 2009; 8(3):CD005004
Anonymous. Wealth of India: Raw materials, Vol X. New Delhi: CSIR; 1976.
Nadkarni KM, Nadkarni AK, editors. Indian Materia Medica, Vol 1. 3rd ed. Mumbai: M/S Popular Prakasan Pvt. Ltd; 1976.
Kirtikar KR, Basu BD, editors. Indian Medicinal Plants, Vol 1. 2nd ed. New Connaught Place, Dehra Dun: M/S Bishen Singh, Mahendra Pal Singh; 1975.
Chopra RN, Nayar SL, Chopra IC, editors. Glossary of Indian Medicinal plants. New Delhi: CSIR; 1956.
Chopra RN, Chopra LC, Handa KD, Kapur LD, editors. Indigenous Drugs of India. 2nd ed. Kolkata: M/S Dhar VN & Sons; 1982.
Zhao TF, Wang X, Rimando AM, Che C. Folkloric medicinal plants: Tinospora sagittata var. cravaniana and Mahonia bealei. Planta Med 1991; 57:505.
Singh KP, Gupta AS, Pendse VK, Mahatma OP, Bhandari DS, Mahawar OO. Experimental and clinical studies on Tinospora cordifolia. J Res Ind. Med. 1975; 10(1):9
Srasquete, C., A. Polo and M. Yúfera. – 1995. Histology and histo- chemistry of the development of the digestive system of larval gilthead seabream, Sparus aurata L. Aquaculture, 130: 79-92
Published
Abstract Display: 563 
PDF Downloads: 556 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.