Delivery System Design in Topically Applied Formulations

Authors

  • Nisha Mary Joseph School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia
  • Senait Shimelis School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia

Abstract

The skin provides a natural physical barrier against particle penetration. Delivery systems design can be used to overcome these barrier properties of the skin. One long-standing approach for improving topical drug delivery uses penetration enhancers which, penetrate into skin to reversibly decrease the barrier resistance. This review focuses on skin penetration pathways, different types of penetration enhancer and the technology for topical drug delivery as well as the probable mechanisms of action.

Keywords: Topical drug delivery, penetration enhancers

DOI

https://doi.org/10.22270/jddt.v8i6.2674

Author Biographies

Nisha Mary Joseph, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia

School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia

Senait Shimelis, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia

School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia

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05-12-2018
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Joseph NM, Shimelis S. Delivery System Design in Topically Applied Formulations. J. Drug Delivery Ther. [Internet]. 2018 Dec. 5 [cited 2025 Apr. 18];8(6):405-20. Available from: https://jddtonline.info/index.php/jddt/article/view/2674

How to Cite

1.
Joseph NM, Shimelis S. Delivery System Design in Topically Applied Formulations. J. Drug Delivery Ther. [Internet]. 2018 Dec. 5 [cited 2025 Apr. 18];8(6):405-20. Available from: https://jddtonline.info/index.php/jddt/article/view/2674