Estimation of Metformin Hydrochloride in Bulk and Formulation by UV - Spectroscopic Area Under Curve Method
Abstract
The current work is carried out for estimation of Metformin Hydrochloride by using area under curve (AUC) method using UV-visible spectrophotometer. For this purpose the wavelength range 221-241 nm was selected. Distilled water was used as a solvent throughout the work. Linearity was observed in concentration range 5-25 µg/ml (R2= 0.994) for the method. The present method was found to be simple and linear which can be used for routine quality control analysis for spectrophotometric estimation of Metformin hydrochloride in bulk.
Keywords: Metformin Hydrochloride, Area under curve, Antidiabetic, λmax.
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6) Beckett A.H, Stenlake J.B , Practical Pharmaceutical Chemistry, 4th edition, CBS publisher and Distributors, New Delhi, 275-295,2002.
7) Chistian G D, Analytical chemistry, six edition , John Wiley and sons, PA, 1-2,604,2003
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9) Saravanan V, Revathi R, Meera N, Method Development and Validation for the Simultaneous Estimation of Lycopene and Ubidecarenone By RP-HPLC in Combined Pharmaceutical Dosage Form. Journal of Drug Delivery and Therapeutics, 2016; 6(5):46-51.
10) Pachpute K, Jadhav S.L, Estimation of Disulfiram in Bulk and Formulation by UV- Spectrophotometric Area Under Curve method, Inventi Rpid:Pharma Analyis & Quality Assurance 2019; 1(2):1-6.
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12) Loni AB, Ghante MR, Sawant SD, Simultaneous UV- Spectroscopic Method for Estimation of Sitagliptin Phosphate and Metformin Hydrochloride in Bulk and Tablet Dosage , Scholar Research Library ,Der Pharm Chemica, 2012,4(3):854-859.
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Kakade VB, Lobhe G, Gandhat SG, Dhobale SM, Patel SG. Estimation of Metformin Hydrochloride in Bulk and Formulation by UV - Spectroscopic Area Under Curve Method. JDDT [Internet]. 15May2019 [cited 18Apr.2024];9(3):163-7. Available from: https://jddtonline.info/index.php/jddt/article/view/2632
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