Formulation and optimization of carbamazepine floating tablets by 23 - factorial design employing Starch-Urea-Borate: A new floating polymer

Authors

  • Rada Santosh Kumar GITAM Institute of Pharmacy, GITAM (Deemed to be University)GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, A.P 530045, INDIA
  • K.P.R. Chowdary Ex-Principal, AU College of Pharmaceutical Sciences, Visakhapatnam

Abstract

Several approaches are currently used to retain the dosage form in the stomach. These include bioadhesive systems, swelling and expanding systems, floating systems   and other delayed gastric emptying devices. The principle of floating tablets offers a simple and practical approach to achieve increased gastric residence time to enhance the bioavailability and to obtain controlled release. Floating tablets are designed based on gas generating principle. Design of floating tablets needs a strong matrix forming polymer. Though several polymers are available for floating tablets, there is a continued need to develop new, effective and efficient polymers for controlled release floating tablets. The major objective of the investigation is to evaluate starch-urea-borate, a new modified starch as a floating matrix former in the design of controlled release floating tablets.

Keywords: Optimisation, Carbamazepine, Starch-Urea-Borate, Floating Tablets

DOI

https://doi.org/10.22270/jddt.v9i2.2576

Author Biographies

Rada Santosh Kumar, GITAM Institute of Pharmacy, GITAM (Deemed to be University)GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, A.P 530045, INDIA

GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, A.P 530045, INDIA

K.P.R. Chowdary, Ex-Principal, AU College of Pharmaceutical Sciences, Visakhapatnam

Ex-Principal, AU College of Pharmaceutical Sciences, Visakhapatnam

Published

15-03-2019
Statistics
Abstract Display: 588
PDF Downloads: 576

How to Cite

1.
Santosh Kumar R, Chowdary K. Formulation and optimization of carbamazepine floating tablets by 23 - factorial design employing Starch-Urea-Borate: A new floating polymer. J. Drug Delivery Ther. [Internet]. 2019 Mar. 15 [cited 2025 Jul. 13];9(2):285-9. Available from: https://jddtonline.info/index.php/jddt/article/view/2576

Issue

Vol. 9 No. 2 (2019): Volume 9, Issue 2 March-April 2019

Section

Research

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

How to Cite

1.
Santosh Kumar R, Chowdary K. Formulation and optimization of carbamazepine floating tablets by 23 - factorial design employing Starch-Urea-Borate: A new floating polymer. J. Drug Delivery Ther. [Internet]. 2019 Mar. 15 [cited 2025 Jul. 13];9(2):285-9. Available from: https://jddtonline.info/index.php/jddt/article/view/2576
Crossref
Scopus
Google Scholar
Europe PMC

Most read articles by the same author(s)

> >>