ENHANCEMENT OF SOLUBILITY AND DISSOULTION RATE OF DOMPERIDONE USING COGRINDING AND KNEADING TECHNIQUE

Abstract

Purpose: Improving the solubility and dissolution rate of domperidone using PEG 4000 and PVP K25 as a carriers in combination by Solid Dispersion Technique. Methods: Solid dispersions of domperidone were prepared using different ratios of PVP and PEG as carrier by co grinding and kneading method. The co grinding mixtures were prepared by mixing appropriate amounts of drug and carriers in different mass ratio in mortar and pestle. In kneading method, minimum quantity of water-ethanol mixture was used for dispersion of drug and carriers. The prepared solid dispersions were characterized for their drug content, in-vitro dissolution studies, FTIR spectroscopy and DSC were performed to identify physiochemical interaction between the drug and carrier and its effect on dissolution behavior.  A comparative evaluation of the dissolution profiles of domperidone solid dispersion tablets and marketed formulation (tablet) was carried out. Results: The prepared formulations showed marked improvement in the solubility and dissolution rate of drug which may be due to decrease in crystallinity of drug and additives.  Formulation (S2) 1:2:2 of DOM:PEG:PVP gives fast dissolution rate 85.77% of drug as compared to  others formulation  and marketed product (MP) in 1hr.   Conclusion: The prepared solid dispersion of the Domperidone with PEG and PVP can improve the solubility and dissolution rate of the drug.

Keywords: Domperidone, PEG, PVP, Solid dispersion, Dissolution rate.