Design and Characterisation of Bi-layer Tablets Containing Simvastatin as Sustained Release and Labetalol HCl as Immediate Release
Abstract
The objective of present investigation is to design and characterise sustained release Simvastatin and immediate release of Labetalol HCl, a bi-layer tablet. The combination therapy of Simvastatin and Labetalol HCl can be useful in severe cardiovascular disease such as hypertension, angina pectoris, congestive heart failure which may occur along with increasing cholesterol level in the blood, while this combination remain preferable choice to the patient as compared to single dosage form. The bi-layer tablet is suitable for sequential release of two drugs in combination which are compatible with each other. Objective of present investigation is to prepare bi-layer tablet in which one layer is sustained while another one is immediate release. For the preparation of bi-layer tablet, different super disintegrants like cross carmellose cellulose, micro crystalline cellulose is used for immediate release and HPMC and Carbapol as controlled release polymer. The pre-formulation parameter such as solubility, melting point, compatibility study (FTIR) were studied. Pre-compression parameter such as angle of repose, bulk density, tapped density, hausner’s ratio and compressibility index were studied. The tablets were evaluated by physical and chemical parameters such as weight uniformity, hardness, thickness, diameter, friability, drug content, disintegration time and in-vitro drug release. The dissolution data were subjected to various release kinetic model to recognize the mechanism of drug release.
Keyword: sustained release tablet, bi-layer tablet, Simvastatin, Labetalol HCl.
DOI
https://doi.org/10.22270/jddt.v9i2-s.2508References
Prabakaran B, Elango K, Ramesh Kumar K, Jaison D. Formulation Development and Evaluation of Gastroretentive Bilayer Floating Tablets of Simvastatin and Telmisartan. International Journal of Pharma Research & Review, 2016; 5(1):9-18.
Kulkarni A, Bhatia M. Development Evaluation of Regio-selective Bilayer Floating Tablets of Atenolol and Lovastatin for Biphasic Release Profile. Iranian Journal of Pharmaceutical Research, 2009; 8(1):15-25.
https://pubchem.ncbi.nlm.gov/compound/Simvastatin.
https://pubchem.ncbi.nlm.nih.gov/compound/Labetalol.
Varma KV. excipients used in the formulation of tablet. Research and reviews journal of chemistry, 2016.
Hilal MM, Hussain MM, Shreen S, Parveen S, Reddy RB. Formulation and Evaluation of Labetalol Hydrochloride Fast Dissolving Tablets. Am. J. PharmTech Res, 2013; 3(5).
Ravi M, Umadevi SK, Venkateswara Reddy B, Navaneetha K. Design and Evaluation of Labetalol Bilayered Tablets. International Journal of Current Trends in Pharmaceutical Research, 2014; 2(5):586-595.
Gurdeep R Chatwal and Sham K Anand. Instrumental methods of Chemical Analysis, 3rd ed, Himalaya Publishing House, Mumbai. 2011, 244.
Indian Pharmacopoeia, Ministry of Health and Family Welfare. Ghaziabad, India: The Indian Pharmacopoeia commission. 2010; 3:2186-2188.
United States Pharmacopoeia, 30th edition NF 25-2007,The Official Compendia of Standards. 643, Pharmacopoeial forum, 28(2), 618.
British Pharmacopoeia. Medicines and Healthcare products Regulatory Agency. London: The Stationery Office, I, 2009, 5872, 7.
Published
Abstract Display: 729 
PDF Downloads: 772 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.