Preparation of solid lipid nanoparticles through various methods using different precursors
Abstract
Now a day there has been exponential increase in interest in developing nanoparticles for novel drug delivery system. Nanoparticles provide many advantages over conventional drug delivery system like improved pharmacokinetic property; enhance bioavailability, smaller drug dose required for the treatment. Recently solid lipid nanoparticles (SLN) materialized as novel approach to oral and parenteral drug delivery system. SLN possess a solid lipid core that can solubilise lipophilic drug. Lipid core was stabilised by using surfactant (emulsifier). SLN can be prepared by using various precursors like emulsion, micro emulsion, and SLM can be prepared by using lipid coated microcrystal. These precursors further proceed to obtain particles of desired size and shape by making use of various techniques and equipment’s. Each precursor show benefits along with some limitations.
Keywords: solid lipid nanoparticles, SLN precursors, membrane contractor, spray dry and congealing, GAMA.
DOI
https://doi.org/10.22270/jddt.v9i2.2461References
Müller R.H., Mäder K, Gohla S, Solid lipid nanoparticles (SLN) for controlled drug delivery-a review of the state of the art. European journal of pharmaceutics and biopharmaceutics, 2000. 50(1):161-177.
Bodmeier R., Wang J., Bhagwatwatar H. Process and formulation variables in the preparation of wax microparticles by a melt dispersion technique. I. Oil-in-water technique for water-insoluble drugs. J Microencapsul 1992; 9:89-98
Bodmeier R., Wang J., Bhagwatwatar H. Process and formulation variables in the preparation of wax microparticles by a melt dispersion technique. 11. W/O/W multiple emulsion technique for water-soluble drugs. J Microencapsul 1992; 9:99-107
Chattopadhyay P., Shekunov B., Yim D., Cipolla D., Boyd B. Farr S. Production of solid lipid nanoparticle suspensions using supercritical fluid extraction of emulsions (SFEE) for pulmonary delivery using the AERx system. Adv Drug Deliv Rev 2007; 6:444–453
Shinoda K., Saito H. The stability of O/W type emulsions as a function of temperature and the HLB of emulsifiers: the emulsification by PIT-method. J Colloid Interface Sci 1969; 30:258–263
Montenegro L., Campisi A., Sarpietro M.G., Carbone C., Acquaviva R., Raciti G., Puglisi G. In vitro evaluation of idebenone-loaded solid lipid nanoparticles for drug delivery to the brain. Drug Dev Ind Pharm 2011; 37:737–746
Hoar T.P., Schulman J.H. Transparent water in oil dispersions: the oleopathic hydromicelle. Nature 1943; 152:102–103
Kreilgaard M. Influence of microemulsions on cutaneous drug delivery. Adv Drug Deliv Rew 2002; 54:S77-S98
Gasco M.R. Method for producing solid lipid microspheres having a narrow size distribution. US5250236 (1993)
Koziara J.M., Lockman P.R., Allen D.D., Mumper R.J. Paclitaxel nanoparticles for the potential treatment of brain tumors. J Control Release 2004; 99:259–269
Battaglia L., Trotta M., Cavalli R. Method for the preparation of solid micro and nanoparticles. WO2008149215 (2008)
Battaglia L., Gallarate M., Cavalli R., Trotta M. Solid lipid nanoparticles produced through a coacervation method. J Microencapsul 2010; 27:78–85
Bianco M.A., Gallarate M., Trotta M., Battaglia L. Amphotericin B loaded SLN prepared with the coacervation technique. J Drug Deliv Sci Tech, 2010; 20:187-191
Chirio D., Gallarate M., Peira E., Battaglia L., Serpe L., Trotta M. Formulation of curcumin- loaded solid lipid nanoparticles produced by fatty acids coacervation technique. J Microencapsul 2011; 28:537–548
Trotta M., Debernardi F., Caputo O. Preparation of solid lipid nanoparticles by a solvent emulsification-diffusion technique. Int J Pharm 2003; 257:153-160
Garcia-Fuentes M., Torres D., Alonso M.J. Design of lipid nanoparticles for the oral delivery of hydrophilic macromolecules. Coll Surf B: Biointerf 2003; 27:159-168
Gallarate M., Trotta M., Battaglia L., Chirio D. Preparation of solid lipid nanoparticles from W/O/W emulsions: Preliminary studies on insulin encapsulation. J Microencaps 2009; 26:394–402
Siekmann B, Westesen K. Investigation on solid lipid nanoparticles prepared by precipitation in o/w emulsion. Eur J Pharm Biopharm 1996; 42:104–109
Sah, H., 2000. Ethyl fomate—alternative dispersed solvent useful in preparing PLGA microspheres. Int. J. Pharm. 195:103–113.
Killeen M.J. Spray drying and spray congealing of pharmaceuticals. In Encyclopedia of Pharmaceutical Technology. Edited by Swarbrick J. Boylan JC 2000
Pilcer G., Amighi K. Formulation strategy and use of excipients in pulmonary drug delivery. Int J Pharm 2010; 392:1-19
Trotta M., Cavalli R., Trotta C., Bussano R., Costa L. Electrospray technique for solid lipid-based particle production. Drug Dev Ind Pharm 2010; 36:431-438
Bussano R., Chirio D., Costa L., Turci F., Trotta M. Preparation and characterization of insulin loaded lipid-based microspheres generated by electrospray. J Disper Sci Technol 2011; 32:1524-1530
A. Maschke, C. Becker, D. Eyrich, J. Kiermaier, T. Blunk, and A. Gopferich, Development of a spray congealing process for the preparation of insulin-loaded lipid microparticles and characterization thereof, Eur. J. Pharm. Biopharm, 2007, 65:175–187
Byrappa K., Ohara S., Adschiri T. Nanoparticles synthesis using supercritical fluid technology – towards biomedical applications. Adv Drug Deliv Rev 2008; 60 299-327
Ribeiro Dos Santos I., Richard J., Pech B., Thies C., Benoit J.P. Microencapsulation of protein particles within lipids using a novel supercritical fluid process Int J Pharm 2002; 242:69–78
Luigi Battaglia L, Gallarate M, Panciani P.P, Ugazio E, Sapino S, Peira E and Chirio D., Techniques for the preparation of solid lipid nano and microparticles,Research gate, 2015; 51-70
Charcosset C., Fessi H. Novel method for preparing solid lipid nanoparticles using a membrane reactor. WO2007000531 (2007)
El-Harati A.A., Charcosset C., Fessi H. Influence of the formulation for solid lipid nanoparticles prepared with a membrane contactor. Pharm Dev Technol 2006; 11:153–157
Published
Abstract Display: 2741 
PDF Downloads: 1776 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.