Preparation, Characterization and Applications of Nanoemulsions: An Insight
Abstract
Nanoemulsions are defined as isotropic, thermodynamically stable, transparent or translucent; dispersions of oil and water stabilized by surfactant molecules (forms an interfacial film) having the droplet size of 20-500nm. Ease of preparation and scale-up, stability and increased bioavailability are features of these formulations which have attracted the attention of researchers. Its basic principle lies in its ability to spontaneously generate fine o/w microemulsion under mild agitation following dilution with aqueous phases. These conditions mimic the digestive motility in the GIT necessary to provide the agitation required for In vivo self emulsification. Unlike emulsions, self-nanoemulsified drug delivery systems (SNEDDS) generates microemulsion with a narrow droplet size distribution of less than 50 nm due to which these systems have also been addressed as nanoemulsions. Nanoemulsions (NE) are lipidic nanoformulations with droplet diameter in nanometer range have established tremendous attention as drug delivery formulations for lipophilic drugs due to their capability to increase solubility, permeation across biological membranes as well as their therapeutic efficiency of lipid soluble drugs due to predictable size-distribution, high drug loading and stability under biological environment. However there is still relatively narrow insight regarding preparation, characterization and applications of nanoemulsions. This limitation unfolds the premise for current review article. In this review, we attempt to explore varying intricacies, methods of preparation, characteristics, and drug delivery applications of nanoemulsions to spike interest of those contemplating a foray in this field.
Keywords: Nanoemulsions, Novel drug delivery system, increased bioavailability.
DOI
https://doi.org/10.22270/jddt.v9i2.2410References
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