Comparative study on prophylactic antibiotic versus empirical antibiotic in prevention of surgical site infection
The main aim of the study was to comparative study of single dose prophylactic antibiotic versus empirical postoperative antibiotics in prevention of surgical site infection. The study was a prospective observational study conducted over a period of 8months. A total of 100 number of surgery cases were selected randomly, to groups of 50 each. The study group received a single dose of antibiotic preoperatively while the control group received 3 to 5 days of empirical antibiotic therapy. Data analysis and statistical analysis was done with the help of graph pad prism trial version software. Student t test was carried out for paired analysis to find P value. There was no significant association of surgical site infection, grades of infection, and other complications. The hospital stay of patients, cost to the patients, and number of antibiotics used in patients were significantly more. The single dose prophylactic antibiotics are better than empirical post operative therapy in reducing the hospital stay and hospital cost to patients. Since the complete eradication of surgical site infection is not possible, only the reduction in infection rate can be achieved to a minimal level.
Keywords: Prophylactic antibiotics, surgical site infection, surgical complications, post operative antibiotics.
2. Nandi PL ,Rajan SS , Mak KC, Chan SC, So YC, Surgical wound infection. Hong Kong Medical Journal. 1999; 5 (1):82-86.
3. Jonathan N, Meakins, M.D, D.S.C, F. A.G.S, and Byron F, Master son, F.D,G.S, Prevention of post operative infection. ACS surgery: Principle and practise 2005.
4. Mangram AJ, MD; Teresa C. Horan, MPH, CIC; Michele L. Pearson, MD; Silver LC, BS; Jarvis WR, MD; Guideline for prevention of surgical site infection. 1999; 251-266.
5. The Biochemical scientist, Mechanisms involved in wound healing 2008:609-615.
6. Anderson DK ,Billiar TR, Dunn DL , Hunter JG ,Mathews JB, Pollock RE, Schwartz’s Principles of Surgery:135.
7. Thejeswi P, Shenoy D,Tauro L, Ram S,Comparative Study Of One-Day Perioperative Antibiotic Prophylaxis Versus Seven Day Postoperative Antibiotic Coverage In Elective Surgical Cases. The Internet Journal of Surgery. 2012; 28(2):1-7
8. NICE clinical guideline 74. NHS Surgical site infection Prevention and treatment of surgical site infection 2008; 74:1-27
9. Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection. JAMA Surg. 2017; 152(8):784-791.
10. Bangaru H, Gaiki VV, Reddy MVR. Comparative study of single dose preoperative antibiotics versus both preoperative and postoperative antibiotics in laparoscopic appendicectomy for nonperforated appendicitis. International Surgery Journal. September 2017; 4(9):3092
11. Zhang C, Zhang L, Liu X, Zhang L, Zeng Z, Li L, Liu G, Jiang H. Timing of Antibiotic Prophylaxis in Elective Caesarean Delivery:AMulti-Center Randomized Controlled Trial land MetaAnalysis, PLOSONE 2015; 10:1371.
12. Malik AZ, Ali Q, Surgical Site Infections after Elective Surgery in Pakistan. Surgipak Study. Journal of Rawalpindi Medical College (JRMC) 2015; 19(3):209-214.
13. Thejeswi P, Shenoy D,Tauro L, Ram S,Comparative Study Of One-Day Perioperative Antibiotic Prophylaxis Versus Seven Day Postoperative Antibiotic Coverage In Elective Surgical Cases. The Internet Journal of Surgery. 2012; 28 (2):1-7
14. Rejab AF, Hassouni MK. The use of single versus multiple doses cefotaxime as a Prophylactic Antibiotic in maxillofacial fractures. Al-Rafidain Dent J. 2012; 12(1):96-101.
15. Shah Z, Kshirsagar N S, Shah S. “Comparison of Single Dose Prophylactic Antibiotics versus five days Antibiotic in Cesarean Section”. Journal of Evolution of Medical and Dental Sciences 2014; 3(12):3123-3129.
16. Wanjare VS, Wanjare SW, Akulwar SL, Tabhane MK, Rahule AS. A Study of Postoperative Wounds Infections with Special Reference to Pseudomonas. J Cont Med A Dent 2014; 2(2):17-21.
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