Carbamazepine Induced Drug Rash with Eosinophilia and Systemic Symptoms
Stabilizes inactivated state of sodium channels, thereby making neurons less excitable may reduce activity of nucleus ventralis of the thalamus or decrease synaptic transmission or summation of temporal stimulation leading to neuronal discharge.A adult of 68 years old patient came to dermatology department with chief complaints of neuralgia over scalp to relieve the symptoms physician prescribed carbamazepine 200mg Po OD. During his 2ndweek of treatment patient developed pain,fever,sore throat followed by skin rash.Better vigilance is necessary for implementation of safe and effective treatment for each individual patient.in order to prevent serious adverse drug reactions of this drug,close monitoring drug treatment course, creating awareness, recognition of the problem and careful management of all the patients who receive medication are essential,because use of carbamazepine causes thrombocytopenia, leukopenia, leukocytosis, eosinophilia, anemia, pruritic and erythematous rashes, urticaria, photosensitivity reactions, alterations in skin pigmentation, exfoliative dermatitis, erythema multiforme and nodosum, purpura, aggravation of disseminated lupus erythematosus,Abnormalities in liver function tests, cholestatic and hepatocellular jaundice, hepatitis; very rare cases of hepatic failure, Pancreatitis ,Pulmonary hypersensitivity characterized by fever, dyspnea, pneumonitis, or pneumonia
Keywords: Carbamazepine, Induced Drug Rash with Eosinophilia and Systemic Symptoms, adverse drug reaction.
2. Tricia Y, Ting MD. Anticonvulsant hypersensitivity syndrome: Identification and management. Current Treatment Options in Neurology. 2007; 9(4):243–248. [PubMed]
3. Bocquet H, Boagot M, Roujeau JC. Drug-induced pseudolymphoma and drug hypersensitivity (Drug rash with eosinophilia and systemic symptoms: DRESS) SeminCutan Med Surg. 1996; 15(4):250–7.[PubMed]
4. Patrice Cacoub, Philippe Musette, Vincent Descamps. The DRESS Syndrome: A Literature Review. Am J Med. 2011; 124(7):588–97. [PubMed]
5. Wang XQ, Lang SY, Shi XB, et al. Cross-reactivity of skin rashes with current antiepileptic drugs in Chinese population. Seizure. 2012; 19:562–566. [PubMed]
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).