Synthesis and Characterization of 1, 3, 4-Oxadiazole Derivatives
Abstract
1,3,4-oxadiazole is a five member heterocyclic ring which is a very important compound for designing potent bioactive agents. This interesting group of compound has different biological activities such as anti-inflammatory, antimicrobial, anticancer, antitubercular, anticonvulsant, anti-HIV, hypogycemic and antioxidant etc. In the present research work, we have synthesized four newly 1,3,4-oxadiazole derive atives derived from existing NSAID Ibuprofen. The purity of compounds was checked by TLC and melting point. The melting point was determined by open capillary methods and uncorrected. Structure of all four newly synthesized compounds was confirmed by spectral analysis (FTIR, and 1HNMR).
Keywords: Oxadiazole, 1, 3, 4-Oxadiazole derivatives, Heterocyclic, Ibuprofen, Cyclic compound.
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