A novel topical phytotherapy for normalization of aberrant leg-anatomical and biochemical risks in failed spine surgery associated with knee-osteoarthritis: A unique case study

  • Apurba Ganguly Chief Scientist in Department of Research and Development, OPTM Research Institute, Kolkata - 700029, India


Objective: The aim of the study was to normalize the aberrant leg-anatomical and biochemical parameters, to relieve pain syndromes and to improve quality of life without revision of failed spine surgery (FSS) and surgical intervention of coexisted knee-osteoarthritis (KOA) correlated with radiological images by specialized topical phytotherapy.

Methods:  A 45year-old gentleman was advice to undergo revision of FSS and surgical intervention for KOA. He refused to do the further surgeries and treated in OPTM Health Care during January-February 2018. Anatomical measurements included  bilateral: the gap at the knee joint between the short head of the biceps femoris and the level of the bed in supine, diameters of muscles at the thigh, the calf, 4cm above and below the patella, angles of straight leg raising, knee flexion and extension in  supine, and biomarkers (Interleukin-10, Tumour necrosis factor-alpha, C-reactive protein, Creatine kinase-muscle  and Aldolase-A) were measured pre- and post-treatment using appropriate protocols. The patient was treated for 12-week with phytoextracts of established seven medicinal plants.

Results: The percentages of improvements for all the above-mentioned abnormal leg-anatomical and biochemical parameters were observed at post-treatment: 63.81, 2.28, 0.81, 5.22, 0.82, 160.00,73.75 and 50.00 respectively for right leg and 69.60, 5.79, 2.79, 9.93, 0.82, 290.00, 85.33 and 54.55 for left leg in case of leg-anatomical features and 87.72, 66.39, 77.27, 22.77 and 48.41 respectively for biomarkers and that for international acclaimed pain parameters under VAS, WOMAC, ODI, LEFS, KPS and BMI were highlighted in the earlier study and the same under KOOS were recorded as pain(86.11), symptoms(89.29), ADL(79.42), Sport & Recreation(75.00) and QOL(68.75) with improved radiological images both lumbar and knee-joints as assessed by KL-grading scales(≥2).

Conclusion: Results showed the deranged leg-anatomical and biochemical risks, together-with impaired international pain parameters during FSS associated with KOA can be normalized by specialized topical phytotherapeutic treatment within 12-week.


Download data is not yet available.

Author Biography

Apurba Ganguly, Chief Scientist in Department of Research and Development, OPTM Research Institute, Kolkata - 700029, India

Department of Research and Development, OPTM Research Institute, Kolkata - 700029, India


1. Felson DT, Epidemiology of hip and knee osteoarthritis, Epidemiol Rev, 1988; 10:1-28.
2. Bijlsma JW, Berenbaum F, Lafeber FP, Osteoarthritis: an update with relevance for clinical practice, Lancet, 2011; 377:2115-2126.
3. Johnson VL, Hunter DJ, The epidemiology of osteoarthritis, Best Pract Res Clin Rheumatol, 2014; 28:5-15.
4. Mabey T, Honsawek S, Role of vitamin D in osteoarthritis: Molecular, cellular, and clinical perspectives, Int J Endocrinol, 2015; 2015: (http://dx.doi.org/10.1155/2015/383918).
5. Li H, Zeng C, Wei J, et al. Serum calcium concentration is inversely associated with radiographic knee osteoarthritis: A cross-sectional study, Medicine, 2016; 95(6).
(DOI: 10.1097/MD.0000000000002838).
6. Slemenda C, Heilman DK, Brandt KD, et al. Reduced quadriceps strength relative to body weight: a risk factor for knee osteoarthritis in women, Arthritis Rheum, 1998; 41(11):1951-1959.
7. Ganguly A, The degenerative changes in lumbar region always lead to bilateral degenerative changes in knee-joints and vice versa: Sensation of pain cannot only be the parameter of degeneration, Anat Physiol, 2015; S3:002doi:10.4172/2161-0940.S4-005.
8. Ganguly A, Degenerative changes in lumbar-region occur simultaneously with bilateral-osteoarthritic changes in knee-joints and vice-versa: Normalisation with topical application of phytoconstituents by specialized techniques involving possible cartilage-regeneration, International Journal of Recent Scientific Research, 2015; 6(9):6331-6346.
9. Weinstein JN, Lurie JD, Olson PR, Bronner KK, Fisher ES, United States' trends and regional variations in lumbar spine surgery: 1992-2003, Spine (Phila Pa 1976), 2006; 31(23):2707-14.
10. Pengel LH, Herbert RD, Maher CG, Refshauge KM, Acute low back pain: systematic review of its prognosis, BMJ, 2003; 327(7410):323.
11. Ganguly A, Ganguly D, Aberrant biomarkers, leg anatomy and pain parameters are the risk factors in lumbar-herniated disc: A novel diagnostic protocol. J Orthopedics Rheumatol, 2018; 5(2):1.
12. Ganguly A, Diagnosis of knee osteoarthritis risk through abnormal musculo-postural features, Int Arch BioMed Clin Res, 2018; 4(1):1-4.
13. Ganguly A, Ganguly D, Evidence-based tropical phytotherapeutic treatment protocol for lumbar slipped disc: An approach with biochemical, anatomical, functional disability and radiological parameters, IOSR Journal of Dental and Medical Sciences, 2018; 17(9):01-20.
14. Ganguly A, Ganguly D, Banerjee SK, Topical phytotherapeutic treatment: Management of normalization of elevated levels of biochemical parameter during osteoarthritic disorders: A prospective study, J Orthopedics Rheumatol, 2018; 5(1):14.
15. Ganguly A, Diagnosis, prevention & phytotherapy for osteoarthritic disorders: pain diagnostic parameters and prevention of OADs. Scholars press, UK: 2017.
16. Thompson D, Pepys MB, Wood SP, The physiological structure of human C-reactive protein and its complex with phosphocholine, Structure, 1999; 7:169-177.
17. Pearle AD, Scanzello CR, George S, Mandl LA, DiCarlo EF, Peterson M, et al. Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings inpatients with osteoarthritis, Osteoarthritis and Cartilage, 2007; 15:516-523.
18. Laureys M, Sion J-P, Slabbynck H, et al. Macromolecular creatine kinase type 1: A serum marker associated with disease, Clin Chem, 1991; 37:430-434.
19. Galarraga B, Sinclair D, Fahie-Wilson MN, Mccrae FC, Hull RG, Ledingham JM, A rare but important cause for a raised serum creatine kinase concentration: two case reports and a literature review, Rheumatology, 2003; 42:186-188.
20. Rehbein-Thoner M, Pffleiderer, The changes in aldolase isoenzyme pattern during development of the human kidney and small intestine-demonstrated in organ extracts of tissue structure, Physiol Chem, 1977; 358G:169-180.
21. Bodian CA, Freedman G, Hossain S, Eisenkraf JB, The visual analog scale for pain: Clinical significance in postoperative patients, Anesthesiology, 2001; 95:1356-1361.
22. Bellamy N, Buchnan WW, Goldsmith CH, Campbell J, Stitt LW, Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to anti-rheumatic drug therapy in patients with osteoarthritis of the hip or knee, J Rheumatol, 1988; 15:1833-1840.
23. Fairbank JCT, Pynsent PB, The Oswestry Disability Index, Spine, 2000; 25(22):2940-2953.
24. Binkley JM, Stratford PW, Lott SA, Riddle DL, The Lower Extremity Functional Scale (LEFS): Scale development, measurement properties, and clinical application, Physical Therapy, 1999; 79:371-383.
25. Schag CC, Heinrich RL, Ganz PA, Karnofsky performance status revisited: Reliability, validity, and guidelines, J Clin Oncology, 1984; 2:187-193.
26. Ferrera LA, ed. Focus on Body Mass Index and Health Research. New York: Nova Science, 2006. ISBN 978-1-59454-963-2.
27. Roos EM, Roos HP, Lohmander LS, Ekdahl C, Beynnon BD, Knee Injury and Osteoarthritis Outcome Score (KOOS)--development of a self-administered outcome measure, J Orthop Sports Phys Ther, 1998; 28(2):88-96.
28. Kellgren JH, Lawrence JS, Radiological assessment of osteo-arthrosis, Ann Rheum Dis, 1957; 16:494-502.
29. American Academy of Orthopaedic Surgeons Joint motion: method of measuring and recording (4thedn). E & S livingstone Publishers, UK: 1965.
30. Ganguly A, Tropical phytotherapeutic treatment for achieving knee symmetry in osteoarthritis-a sustainable approach, Int J Phytomed, 2014; 6:489-509.
31. Ganguly A, Normalization of varus/valgus deformities in osteoarthritis by external application of phytoconstituents: confirmed with anatomical observations and biochemical profiles and radiological images, Ant Physiol Curr Res, 2016; 6:224.
32. Ganguly A, Topical phytotherapy is the nobel approach for revision of total knee replacement: a unique case study, J Orthop Rheumatol, 2018; 5:1-5.
33. Lee MJ, Hacquebord J, Varshney A, et al. Risk factors for medical complication after lumbar spine surgery: a multivariate analysis of 767 patients, Spine (Phila Pa 1976), 2011; 36(21):1801-1806.
34. Rao SB et al. Risk factors for surgical site infections following spinal fusion procedures: A case-control study, Clin Infect Dis, 2011; 53:686.
35. Schoenfeld AJ, Ochoa LM, Bader JO, Belmont PJ, Risk factors for immediate postoperative complications and mortality following spine surgery: A study of 3475 patients from the national surgical quality improvement program, The Journal of Bone & Joint Surgery, 2011; 1577. DOI: 10.2106/JBJS.J.01048
36. Reis RC, de Oliveira MF, Rotta JM, Botelho RV, Risk of complications in spine surgery: a prospective study, Open Orthop J, 2015; 9:20-25.
37. Passias PG, Poorman GW, Delsole E, Zhou PL, Horn SR, Jalai CM, Vira S, Diebo B, Lafage V, Adverse outcomes and prediction of cardiopulmonary complications in elective spine surgery, Global Spine Journal, 2018; 8(3):218-223.
38. Ganguly A, Ganguly D, A novel approach for failed lumbar spine surgery with topical phytotherapeutic treatment: a unique case study, Journal of Drug Delivery & Therapeutics, 2018; 8(6-s):135-140
39. Schmorl G, Junganns H, Die gesunde und kranke Wirbelsaule in Rontgenbildund Klinik, Stuttgart, 1951.
40. Heliövaara M, Risk factors for low back pain and sciatica, Annals of Medicine, 1989; 21(4):257-264.
41. Karahan A, Kav S, Abbasoglu A, Cogan N, Low back pain: Prevalence and associated risk factors among hospital staff, Journal of Advanced Nursing, 2009; 65(3):516-524.
42. Begg AC, Falconer MA, Plain radiography in intraspinal protrusion of lumbar intervertebral discs: a correlation with operative findings, Br J Surg, 1949; 36:225-239.
43. Hadley LA, Anatomico-roentgenographic studies of the spine, Springfield: Thomas, 1964; 416-417.
44. Apple FS, Hellsten Y, Ciarkson PM, Early detection of skeletal muscle injury by assay of creatine kinase MM Isoforms in serum, Clin Chem, 1988; 34(6):1102-1104.
45. Belcaro G, Dugall M, Luzzi R, Hosoi M, Ledda A, et al. Phytoproflex®: supplementary management of osteoarthritis: a pilot, open, supplement registry, Minerva Med, 2017; 109:88-94.
202 Views | 191 Downloads
How to Cite
Ganguly A. A novel topical phytotherapy for normalization of aberrant leg-anatomical and biochemical risks in failed spine surgery associated with knee-osteoarthritis: A unique case study. JDDT [Internet]. 15Feb.2019 [cited 26Oct.2021];9(1-s):301-6. Available from: https://jddtonline.info/index.php/jddt/article/view/2244