Chitosan-based transdermal drug delivery systems to overcome skin barrier functions
Abstract
Transdermal drug delivery system has been developed or being developed to vanquish the downsides associated with conventional strategies as it avoids first pass hepatic metabolism, improved patient compliances, easy termination of therapy, possibility of self-administration etc. The main challenge in designing transdermal patch is to overcome the low permeability of skin. Several strategies have been developed to overcome the barrier properties and to enhance the transportation of drug molecules across the skin. In the last decades numerous transdermal patches fabricated from polysaccharides have been reported. There has been a growing interest in using chitosan in transdermal formulations thanks to their biocompatibility, non-toxicity, film forming ability, non- skin irritancy etc. This article highlights the application of chitosan in the development of transdermal drug delivery systems such as microneedles, films etc.
Keywords: Transdermal drug delivery, first pass hepatic metabolism, low permeability, microneedles
DOI
https://doi.org/10.22270/jddt.v9i1.2180References
Pegoraro C, MacNeil S, Battaglia G. Transdermal drug delivery: from micro to nano. Nanoscale. 2012; 4:1881−1894.
Tahara Y, Honda S, Kamiya N, Piao H, Hirata A, Hayakawa E, Fujii T, Goto M. A solid-in-oil nanodispersion for transcutaneous protein delivery. Journal of Controlled Release. 2008; 131:14−18.
Thakur VK, Thakur MK, Recent Advances in Graft Copolymerization and Applications of Chitosan: A Review, ACS Sustainable Chemistry & Engineering, 2014, 2:2637-2652.
Rabea EI, Badawy MET., Stevens CV, Smagghe G, Steurbaut W, Chitosan as Antimicrobial Agent: Applications and Mode of Action, Biomacromolecules, 2003, 4:1457-1465.
Mahapatro A, Singh DK, Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines, Journal of Nanobiotechnology, 2011, 9:1-11.
Elgadir MA, Uddin MS, Ferdosh S, Adam A, Chowdhury AJ K, Sarker MZI, Impact of chitosan composites and chitosan nanoparticle composites on various drug delivery systems: A review, Journal of Food and Drug Analysis, 2015, 23:619-629.
Allena RT, Yadav HKS, Sandina S, Sarat Chandra Prasad M, Preparation and evaluation of transdermal patches of metformin hydrochloride using natural polymer for sustained release, International Journal of Pharmacy and Pharmaceutical Sciences 2012, 4.
Ali HSM, Hanafy AF, Glibenclamide Nanocrystals in a Biodegradable Chitosan Patch for Transdermal Delivery: Engineering, Formulation, and Evaluation, Journal of Pharmaceutical Sciences 2017, 106:402-410.
Balamurugan M, Agrawal SS, Formulation and evaluation of chitosan based bioadhesive transdermal drug delivery systems of lisinopril for prolonged drug delivery, Der Pharmacia Sinica, 2013, 4:1-7.
Behin SR, Punitha IS, Saju F, Development of matrix dispersion transdermal therapeutic system containing glipizide, Der Pharmacia Lettre, 2013, 5:278-286.
Can AS, Erdal MS, Gungor S, Ozsoy Y, Optimization and characterization of chitosan films for transdermal delivery of ondansetron, Molecules (Basel, Switzerland), 2013, 18:5455-5471.
Sarkar G, Orasugh JT, Saha NR, Roy I, Bhattacharyya A, Chattopadhyay AK, Rana D, Chattopadhyay D, Cellulose nanofibrils/chitosan based transdermal drug delivery vehicle for controlled release of ketorolac tromethamine, New Journal of Chemistry, 2017, 41:15312-15319.
Cui Z, Zheng Z, Lin L, Si J, Wang Q, Peng X, Chen W, Electrospinning and crosslinking of polyvinyl alcohol/chitosan composite nanofiber for transdermal drug delivery, Advances in Polymer Technology, 2018, 37:1917-1928.
Vediappan V, Subramanian K, Fabrication and evaluation of chitosan-gelatin composite film as a drug carrier for in vitro transdermal delivery, International Journal of Pharmaceutical Sciences and Research 5: 438-447
Hemant K, Shivakumar H, Development of Chitosan Acetate Films for Transdermal Delivery of Propranolol Hydrochloride, Tropical Journal of Pharmaceutical Research, 2010, 9:197-203
Kashinatha BP, Shivakumar S, Devprakash, Prashant S, Design and evaluation of transdermal film of valsartan by using modified polymer, Journal of Pharmacy Research, 2012, 5:2823-2829
Kim JH, Kim S, Kwon IB, Hyun Kim M, Lim J, Simple fabrication of silver hybridized porous chitosan-based patch for transdermal drug-delivery system, Materials Letters, 2013, 95:48-51.
Kim JH, Lim JI, Park HK, Porous chitosan-based adhesive patch filled with poly(l-3,4-dihydroxyphenylalanine) as a transdermal drug-delivery system, Journal of Porous Materials, 2013, 20:177-182.
Maji P, Gandhi A, Hana S, Maji N, Preparation and Characterization of Maleic Anhydride Cross-Linked Chitosan-Polyvinyl Alcohol Hydrogel Matrix Transdermal Patch, Journal of PharmaSciTechi, 2013, 2:62-67.
Ramesh Y, Sireesha V, Transdermal patch of ramipril loaded chitosan nanoparticles dispersed in carbopol gel, Journal of Drug Delivery & Therapeutics, 2017, 7(6):56-65
Sadhasivam L, Transdermal patches of chitosan nanoparticles for insulin delivery, International Journal of Pharmacy and Pharmaceutical Sciences, 2015, 7:84-88
Shinde A, Shinde A, More H, Design and evaluation transdermal drug delivery system of gliclazide, Asian Journal of Pharmaceutics, 2010, 4:121-129
Siddaramaiah, Kumar P, Divya KH, Mhemavathi BT, Manjula DS, Chitosan/HPMC Polymer Blends for Developing Transdermal Drug Delivery Systems, Journal of Macromolecular Science, Part A, 2006, 43:601-607.
Thakur G, Singh A, Singh I, Formulation and evaluation of transdermal composite films of chitosan-montmorillonite for the delivery of curcumin, International journal of pharmaceutical investigation, 2016, 6:23-31.
Varshosaz J, Jaffari F, Karimzadeh S, Development of bioadhesive chitosan gels for topical delivery of lidocaine, Scientia Pharmaceutica, 2006, 74:209.
Venugopal V, Jayachandran, Transdermal delivery of insulin by biodegradable chitosan nanoparticles: Exvivo and in vivo studies, Iranian Journal of Pharmaceutical Sciences, 8: 315-321
Chen MC, Lai KY, Ling MH, Lin CW, Enhancing immunogenicity of antigens through sustained intradermal delivery using chitosan microneedles with a patch-dissolvable design, Acta Biomaterialia, 2018, 65:66-75.
Chen MC, Ling MH, Lai KY, Pramudityo E, Chitosan Microneedle Patches for Sustained Transdermal Delivery of Macromolecules, Biomacromolecules, 2012, 13:4022-4031.
Chen MC, Huang SF, Lai KY, Ling MH, Fully embeddable chitosan microneedles as a sustained release depot for intradermal vaccination, Biomaterials, 2013, 34:3077-3086.
Marin A, Andrianov AK, Carboxymethylcellulose–Chitosan-coated microneedles with modulated hydration properties, Journal of Applied Polymer Science, 2011, 121:395-401.
Justin R, Román S, Chen D, Tao K, Geng X, Grant RT, MacNeil S, Sun K, Chen B, Biodegradable and conductive chitosan–graphene quantum dot nanocomposite microneedles for delivery of both small and large molecular weight therapeutics, RSC Advances, 2015, 5:51934-51946.
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