Formulation and characterization of choline fenofibrate sustained release capsule
Abstract
The drug ABT-335 (Fenofibricacid ) choline fenofibrate found to be useful in the treatment of dyslipidemia as compare with other fibrate. So the present investigation to developed mini-tablets to overcome the dose dumping problem by regular shape, uniformity, smooth surface excellent size and encapsulated in capsule to improve the efficacy and bioavailability of the drug. Different formulations were developed by utilizingcontrolling of the release rate and gel forming polymers like microcrystalline cellulose, hypromellose by dry granulation technique. Among all formulation SRM-3 having the drug release for longer period of time as compare to other formulation. SRM-3 was found to be stable during stability study for one month.
Keywords: ABT-335 (Fenofibric acid) choline fenofibrate, like microcrystalline cellulose, hypromellose, sustained release matrix tablet.
DOI
https://doi.org/10.22270/jddt.v8i6-s.2124References
Sastry SV., Nyshdham JR., Fix JA. Recent technological advances in oral drug delivery: A review. Pharm Sci and Tech Today. 2000; 3:138-145.
Seager H. “Drug Delivery products and Zydus fast dissolving dosage forms”. J. Pharm. Pharmacology.; 1998, 50(4):375-382.
Lee TWY, Robinson JR. Remington: The Science and Practice of Pharmacy, Lippincott Williams and Wilkins, Maryland, 20thed. 2000; 1069-70.
Loyd V. Allen J, Nicholas G. Popovich, Howard C. Ansel, 8thed. Ansel: Pharmaceutical dosage forms and drug delivery system, Lippincott Williams and Wilkins, Philadelphia, 2006; 260-275.
Jain NK., Advances in controlled and Novel Drug Delivery, 2000. CBS publications, New Delhi.268-69.
Krishnaiah YSR, Karthikeyan RS, Gouri SV, Satyanarayana V. Three-layer guar gum matrix tablet formulations for oral controlled delivery of highly soluble trimetazidinedihydrochloride. J. of Control Rel. 2002; 81:45-56.
Lachman L, Lieberman HA, Kanig JL. The theory and practice of industrial pharmacy. 3rd ed. Mumbai: Vargheese Publishing House; 1991. p. 296-302.
Indian Pharmacopoeia, Government of India, Ministry of Health and Family Welfare. Delhi: Controller of Publications; 1996. Vol 2. p. 182.
United State Pharmacopeia 31, The National Formulary. USPharmacopeialConventi on. Washington DC: Board of Trustees publication; 2008. Vol 1. p. 272.
Vidyadhara S, Choudhary YA, Murthy TE, Rao MV, Reddy KN. Influence of electrolyte on controlled release of Ambroxol hydrochloride from methocel matrix tablet. Pharma Review. 2006; 101–04.
Varshosaz J, Tavakoli N, Roozbahani F. Formulation and in vitro characterization of Captopril floating extended release tablet. Drug Deliv. 2006; 13:277–85.
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