Study of the hyperglycemic condition in diseases of liver in non-obese clinical patients

Authors

  • Chander Jeet Singh Department of Biochemistry, Sri Satya Sai University of Technology & Medical Sciences, Sehore-466001
  • Dinesh Kumar Department of Biochemistry, Sri Satya Sai University of Technology & Medical Sciences, Sehore-466001

Abstract

Hyperglycemia is best documented by Whipple´s triad: symptoms compatible with hypoglycemia, low blood glucose concentration and alleviation of symptoms after the glucose concentration is raised. In experimental studies in healthy adults, fifteen out of the 19 patients who developed hypoglycaemia on the fasts during MT were re-tested 3 to 4 months after cessation of therapy. Fasting tolerance had improved in all of them. It had become normal in 10 out of 15 patients (67%). In 5 patients, blood glucose levels still fell below 2.7 mmol/l (range 2.0 to 2.6 mmol/l) after 16 hours of fasting. However, none had any symptoms.

Keywords: Hypertension, Diabetes mellitus, Glucose, Glycolysis

DOI

https://doi.org/10.22270/jddt.v8i6-s.2115

Author Biographies

Chander Jeet Singh, Department of Biochemistry, Sri Satya Sai University of Technology & Medical Sciences, Sehore-466001

Department of Biochemistry, Sri Satya Sai University of Technology & Medical Sciences, Sehore-466001

Dinesh Kumar, Department of Biochemistry, Sri Satya Sai University of Technology & Medical Sciences, Sehore-466001

Department of Biochemistry, Sri Satya Sai University of Technology & Medical Sciences, Sehore-466001

References

Viardot A, Grey ST, Mackay F, and Chisholm D, “Potential antiinflammatory role of insulin via the preferential polarization of effector T cells toward a T helper 2 phenotype,” Endocrinology, 2007; 148(1):346–353.

Puskas F, Grocott HP, White WD, Mathew JP, Newman MF, et al. Intraoperative hyperglycemia and cognitive decline after CABG. Ann Thorac Surg 2007; 84:1467–1473.

Ambiru S, Kato A, Kimura F, Shimizu H, Yoshidome H, et al. Poor postoperative blood glucose control increases surgical site infections after surgery for hepato-biliary-pancreatic cancer: a prospective study in a high-volume institute in Japan. J Hosp Infect 2008; 68:230–233.

Park C, Hsu C, Neelakanta G, Nourmand H, Braunfeld M, et al. Severe intraoperative hyperglycemia is independently associated with surgical site infection after liver transplantation. Transplantation 2009; 87:1031–1036.

Parekh J, Niemann CU, Dang K, Hirose R. Intraoperative hyperglycemia augments ischemia reperfusion injury in renal transplantation: a prospective study. J Transplant 2011; 652458.

Vriesendorp TM, DeVries JH, Hulscher JB, Holleman F, van Lanschot JJ, et al. Early postoperative hyperglycaemia is not a risk factor for infectious complications and prolonged in-hospital stay in patients undergoing oesophagectomy: a retrospective analysis of a prospective trial. Crit Care 2004; 8:R437–442.

Okabayashi T, Ichikawa K, Namikawa T, Sugimoto T, Kobayashi M, et al. Effect of perioperative intensive insulin therapy for liver dysfunction after hepatic resection. World J Surg 2011; 35:2773–2778.

Behrends M, Martinez-Palli G, Niemann CU, Cohen S, Ramachandran R, et al. Acute hyperglycemia worsens hepatic ischemia/reperfusion injury in rats. J Gastrointest Surg 2010; 14:528–535.

Sugiyama Y, Ishizaki Y, Imamura H, Sugo H, Yoshimoto J, et al. Effects of intermittent Pringle’s manoeuvre on cirrhotic compared with normal liver. Br J Surg 2010; 97:1062–1069.

Han S, Kim G, Lee S, Kwon CD, Gwak M, et al. Comparison of the tolerance of hepatic ischemia reperfusion injury in living donors: Macrosteatosis versus microsteatosis. Liver Transpl. 2014.

Greenhill C Liver transplantation: Macrosteatosis and microsteatosis respond differently to intermittent hepatic inflow occlusion. Nat Rev Gastroenterol Hepatol. 2014.

Derichard A, Robin E, Tavernier B, Costecalde M, Fleyfel M, et al. Automated pulse pressure and stroke volume variations from radial artery: evaluation during major abdominal surgery. Br J Anaesth 2009; 103:678–684.

Dunki-Jacobs EM, Philips P, Scoggins CR, McMasters KM, Martin RC 2nd. Stroke volume variation in hepatic resection: a replacement for standard central venous pressure monitoring. Ann Surg Oncol 2014; 21:473–478.

Maeda H, Okabayashi T, Nishimori I, Yamashita K, Sugimoto T, et al. Hyperglycemia during hepatic resection: continuous monitoring of blood glucose concentration. Am J Surg 2010; 199:8-13.

Akhtar S, Barash PG, Inzucchi SE. Scientific principles and clinical implications of perioperative glucose regulation and control. Anesth Analg 2010; 110:478–497.

Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 2003; 37:1202–1219.

Chau GY, Lui WY, King KL, Wu CW. Evaluation of effect of hemihepatic vascular occlusion and the Pringle maneuver during hepatic resection for patients with hepatocellular carcinoma and impaired liver function. World J Surg 2005; 29:1374–1383.

Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 2004; 240:205–213.

Han S, Kim GS, Choi SJ, Ko JS, Gwak MS, et al. Liver transplantation using grafts of living donors with isolated un-conjugated hyper-bilirubinemia: a matched case-control study. Transpl Int 2013; 26:623–630.

Published

2018-12-15
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How to Cite

1.
Singh CJ, Kumar D. Study of the hyperglycemic condition in diseases of liver in non-obese clinical patients. J. Drug Delivery Ther. [Internet]. 2018 Dec. 15 [cited 2026 Jan. 21];8(6-s):209-12. Available from: https://jddtonline.info/index.php/jddt/article/view/2115

How to Cite

1.
Singh CJ, Kumar D. Study of the hyperglycemic condition in diseases of liver in non-obese clinical patients. J. Drug Delivery Ther. [Internet]. 2018 Dec. 15 [cited 2026 Jan. 21];8(6-s):209-12. Available from: https://jddtonline.info/index.php/jddt/article/view/2115