Formulation and in-vitro evaluation of Glipizide (Anti diabetic drug) Liposphere

  • Sarika Saini Asst. Professor, Motherhood University, Roorkee, Haridwar, Uttarakhand, India
  • Aman Mittal GRD (PG) institute of Management and technology, Dehradun, Uttarakhand, India
DOI https://doi.org/10.22270/jddt.v8i6-s.2096

Abstract

Objective- The aim of the present study was to formulate and in- vitro study of glipizide liposphere by using melt dispersion technique.


Methods- Glipizide Liposphere system composed of paraffin wax, Stearic acid as lipid phase and sodium lauryl sulphate as surfactant. Glipizide lipospheres were prepared by using melt dispersion technique. Formulation of Glipizide was evaluated such as organoleptic properties, particle size, drug content, entrapment efficiency in-vitro study and stability of the lipospheres.


Result- The formation of glipizide lipospheres by using melt dispersion technique was done successfully. All the formulations have off- white in colour, characteristic odour and spherical shape. The formulation A4 has particle size 19.65 μm, drug content 84.93 %, entrapment efficiency 80.75 % and the percentage drug release was carried out by using USP type 2 dissolution apparatus in 6.8 pH phosphate buffer solution and drug release of glipizide lipospheres within 12 hrs was found to be 74.06 %.stability study of glipizide lipospheres revealed that the formulation was stable at 5oC ± 3oC.


Keywords- Lipospheres, Glipizide, Paraffin wax, Melt dispersion method, Dissolution Apparatus, Stability study

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Author Biographies

Sarika Saini, Asst. Professor, Motherhood University, Roorkee, Haridwar, Uttarakhand, India

Asst. Professor, Motherhood University, Roorkee, Haridwar, Uttarakhand, India

Aman Mittal, GRD (PG) institute of Management and technology, Dehradun, Uttarakhand, India

GRD (PG) institute of Management and technology, Dehradun, Uttarakhand, India

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1.
Saini S, Mittal A. Formulation and in-vitro evaluation of Glipizide (Anti diabetic drug) Liposphere. JDDT [Internet]. 15Dec.2018 [cited 19Apr.2024];8(6-s):116-9. Available from: https://jddtonline.info/index.php/jddt/article/view/2096
Issue
Vol 8 No 6-s (2018): VOLUME 8, ISSUE 6-s Nov-Dec 2018
Section
Research
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