Role of Kalmegha (Andrographis paniculata (Burm.F.) Wall. Ex Nees) in treating Vatarakta (Gout)
Andrographis paniculata (Burm.f.) Wall. Ex. Nees (A. Paniculata), i.e. Kalmegha is a medicinal plant traditionally used for various diseases such as fever, diarrhea, worm infestation, hepatic and skin diseases. Modern studies have also explicitly revealed that A. Paniculata has a wide range of pharmacological effects such as anti-inflammatory, anti-hyperglycemic, anti-diarrhoeal, anti-viral, anti-malarial, hepato-protective, anti-cancer, anti-human immunodeficiency virus (HIV), and also work as an immune stimulator. On the other hand, Gout (Vatarakta) is one common metabolic disorder which affects over 1% of the world’s adult population.
Objective: To assess the clinical efficacy of A.Paniculata in Gouty Arthritis.
Study Design: A clinical research, prospective in style, wherein a hypothesis, based on the previous studies on the various effects of A. Paniculata, was made; to assess its efficacy in treating Gout.
Methodology: Randomly selected patients (n = 31) were administered powder of A. Paniculata, 2 gms thrice daily with water, for 45 days with a follow-up in every 15 days for one month. Assessment of the treatment was based on before treatment (BT) and after treatment (AT) effects of A. Paniculata on the parameters namely; subjective, i.e. the symptoms of Gout and objective, i.e. the levels of Serum Uric Acid.
Results: In subjective parameters, Wilcoxon non-parametric test was used. The outcome shows that except the symptom i.e. Pallor (shwetata), in all other symptoms of Gout, p value was either < 0.05 or < 0.01, which is considered to be significant to highly significant. In objective parameter, Z test was used, in which the outcome of p value was < 0.01, which indicates that the effect of A.Paniculata on Serum Uric Acid is highly significant.
Keywords: Kalmegha, Andrographis paniculata, Gout, Vatarakta, Serum Uric Acid, Clinical Studies
2. Clayton L. Thomas (Editor), Taber’s Cyclopedic Medical Dictionary, 16th Edition, F.A.Davis Company, Page – 756.
3. Tripathi B, Charaka Samhita of Agnivesh, Elaborated by Charaka and Dridhbala, Volume – II, with Charaka-Chandrika Hindi commentary, Fourth edition 1996, Chaukhambha Subharati Prakashan, Varanasi, Chikitsasthan, 29/20.
4. Kulyal P., Tiwari U.K., Shukla A. and Gaur A.K. Chemical constituents isolated from Andrographis paniculata. Ind. J. Chem., 2010; 49B:356-359.
5. Dr. Jharkhandey Ojha, Ph.D and Dr.Umapati Mishra, MD (Ayu.), Dhanwantari Nighantu, Chaukhambha Subharati Prakashan, Varanasi, Guduchyadi Prathamo Varga, Shloka – 257.
6. Bapalal G. Vaidya, Nighantu Adarsh, Chaukhambha Bharati Academy, Varanasi, Vasadi Varga, Page - 229.
7. Prof. Priya Vrat Sharma, Priya Nighantu, Chaukhambha Surbharti Prakashan, Varanasi, Shatpushpadi Varga, Shloka – 135-136.
8. Bu-Chin Y., Chen-Road H., Wang-Chuan C. and Juei-Tang C. Antihyperglycemic effect of andrographolide in streptozotocin- induced diabetic rats. Planta Med., 2003; 69:1075-1079.
9. Gupta S., Choudhry M. A., Yadava J. N. S., Srivastava V. and Tandon J.S. Antidiarrhoeal activity of diterpenes of Andrographis paniculata (Kal-Megh) against Escherichia coli enterotoxine in in vivo models. Int. J. Crude Drug Res., 1990; 28:273-283.
10. Gupta S., Yadava J. N. S. and Tandon J. S. Antisecretory (antidiarrhoel) activity of Indian medicinal plants against Escherichia Coli enterotoxin-induced secretion in rabbit and guinea pig ileal loop models. Pharm. Biol., 1993; 31:198-204.
11. Wiart C., Kumar K., Yusof M. Y., Hamimah H., Fauzi Z. M. and Sulaiman M. Antiviral properties of ent-labdene diterpenes from Andrographis paniculata Nees, inhibitors of herpes simplex virus type 1. Phytother. Res., 2005; 19:1069-1070.
12. Mishra P., Pal N. L., Guru P. Y., Katiyar J. C., Srivastava V. and Tandon J. S. Anti-malarial activity of Andrographis paniculata (Kalmegh) against Plasmodium berghei NK65 in Mastomys natalensis. Int. J. Pharmacogn., 1992; 30:263-274.
13. Clander R., Srivastava V., Tandon J. and Kapoor N.K. Anti-hepatotoxic activity of diterpenes of Andrographis paniculata (Kal-Megh) against Plasmodium berghei induced hepatic damage in Mastomys natalensis. Int. J. Pharmacogn., 1995; 33:135–138.
14. Cheung H. Y., Cheung S. H., Li J., Cheung C. S., Lai W. P., Fong W. F. and Leung F. M. Andrographolide isolated from Andrographis paniculata induces cell cycle arrest and mitochondrialmediated apoptosis in human leukemic HL-60 cells. Planta Med., 2005; 71:1106-1111.
15. Calabrese C., Berman S. H., Babish J. G., Ma X., Shinto L., Dorr M, Wells K., Wenner C.A. and Standish L.J. A phase I trial of andrographolide in HIV positive patients and normal volunteers. Phytoether. Res., 2000; 14:333-338.
16. Puri A., Saxena R., Saxena R. P., Saxena K. C., Srivastava V. and Tandon J. S. Immunostimulant agents from Andrographis paniculata. J. Nat. Prod., 1993; 56:995-999.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).