EVALUATION AND QUALITY CONTROL OF NASAL SPRAY

Authors

  • Ramesh Shankarrao Kalkotwar Associate Prof. Dept. of QA, SND College of Pharmacy, Yeola, Nashik
  • Vidya V Bankar Patil Dept. of Quality Assurance, SND College of Pharmacy, (Under Uni. of Pune) Yeola, Dist Nashik 423 401
  • Ankita Manibhai Patel Dept. of Quality Assurance, SND College of Pharmacy, (Under Uni. of Pune) Yeola, Dist Nashik 423 401
  • Swati D. Tathe Dept. of Quality Assurance, SND College of Pharmacy, (Under Uni. of Pune) Yeola, Dist Nashik 423 401
  • Swati S. Rawat Dept. of Pharmaceutics, SND College of Pharmacy, (Under Uni. of Pune) Yeola, Dist Nashik 423 401

Abstract

Nasal drug delivery has now been recognized as a very promising route for delivery of therapeutic compounds including biopharmaceuticals. This route is also advisable for drugs undergoing extensive first pass effect. The present article highlights the evaluation parameters of nasal spray, suspension, and solutions. While formulating the nasal drug delivery formulations various parameters are to be consider such as Appearance, Color, and Clarity, Identification, Drug content (Assay), Impurities and Degradation Products, Preservative(s) and Stabilizing Excipient(s) Assay, Pump Delivery, Spray content uniformity, Spray Content Uniformity (SCU) through Container Life, Spray Pattern and Plume Geometry, Droplet Size Distribution, Particle size distribution (suspension),  Microscopic Evaluation (Suspensions), Foreign Particulates,  Microbial limit,  Preservative Effectiveness, Net Content and Weight Loss (Stability), Leachables (Stability), PH, Osmolality.

 

Key words: Nasal spray, Evaluation, Quality control, Drug delivery system.

DOI

https://doi.org/10.22270/jddt.v2i4.202

Author Biographies

Ramesh Shankarrao Kalkotwar, Associate Prof. Dept. of QA, SND College of Pharmacy, Yeola, Nashik

Associate Professor,
Dept. of Quality Assurance,
SND College of Pharmacy,
(Under Uni. of Pune)
Yeola, Dist Nashik 423 401

India

Vidya V Bankar Patil, Dept. of Quality Assurance, SND College of Pharmacy, (Under Uni. of Pune) Yeola, Dist Nashik 423 401

Student of PG,

Dept. of Quality Assurance,
SND College of Pharmacy,
(Under Uni. of Pune)
Yeola, Dist Nashik 423 401, INDIA

Ankita Manibhai Patel, Dept. of Quality Assurance, SND College of Pharmacy, (Under Uni. of Pune) Yeola, Dist Nashik 423 401

Student of PG,

Dept. of Quality Assurance,

SND College of Pharmacy,

(Under Uni. of Pune)
Yeola, Dist Nashik 423 401, India

Swati D. Tathe, Dept. of Quality Assurance, SND College of Pharmacy, (Under Uni. of Pune) Yeola, Dist Nashik 423 401

Student of PG,

Dept. of Quality Assurance,
SND College of Pharmacy,
(Under Uni. of Pune)
Yeola, Dist Nashik 423 401,India

Swati S. Rawat, Dept. of Pharmaceutics, SND College of Pharmacy, (Under Uni. of Pune) Yeola, Dist Nashik 423 401

Principal,

SND College of Pharmacy,
(Under Uni. of Pune)
Yeola, Dist Nashik 423 401

Published

15-07-2012
Statistics
Abstract Display: 3260
PDF Downloads: 2982

How to Cite

1.
Kalkotwar RS, Bankar Patil VV, Patel AM, Tathe SD, Rawat SS. EVALUATION AND QUALITY CONTROL OF NASAL SPRAY. J. Drug Delivery Ther. [Internet]. 2012 Jul. 15 [cited 2025 Mar. 27];2(4). Available from: https://jddtonline.info/index.php/jddt/article/view/202

Issue

Vol. 2 No. 4 (2012): Volume 2, Issue 4, July-August 2012

Section

Mini Review

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

How to Cite

1.
Kalkotwar RS, Bankar Patil VV, Patel AM, Tathe SD, Rawat SS. EVALUATION AND QUALITY CONTROL OF NASAL SPRAY. J. Drug Delivery Ther. [Internet]. 2012 Jul. 15 [cited 2025 Mar. 27];2(4). Available from: https://jddtonline.info/index.php/jddt/article/view/202
Crossref
Scopus
Google Scholar
Europe PMC