THERAPEUTIC MICROEMULSION OF CURCUMIN FOR THE MANAGEMENT OF OSTEOARTHRITIS
Abstract
Curcumin (diferuloylmethane) is a natural polyphenolic compound with potent anti-inflammatory, anticancer and antioxidant activities. However, its bioavailability is low as it is poorly absorbed in the gastrointestinal tract. Microemulsions offer the potential to improve the solubility and bioavailability of bioactive compounds; the present work investigated the topical delivery potential of microemulsion gel loaded with curcumas. Curcumin microemulsion was prepared by spontaneous emulsification method using oil (Oleic acid), surfactant:cosurfactant (Smix) (Ethanol and Tween 80, Span 80 and n Butanol) and water. The optimized formulations of microemulsions were subjected to thermodynamic stability tests. After stability study, stable formulation was characterized for droplet size, pH determination, centrifugation, % drug content in microemulsion, zeta potential and vesicle size measurement and then microemulsion gel were prepared and characterized for spreadability, measurement of viscosity, drug content, In-vitro diffusion, in-vitro release data. Tween 80, Span 80 was selected as surfactant, ethanol, n Butanol as co surfactant and Oleic acid as oil component based on solubility study. The optimized formulation contained Curcumin (10 mg). The in vitro drug release from curcumin microemulsion gel was found to be considerably higher in comparison to that of the pure drug. The in-vitro diffusion of microemulsion gel was significantly good. Based on this study, it can be concluded the solubility and permeability of curcumin can be increased by formulating into microemulsion gel.
Keyword: Curcumin, Microemulsion, In-vitro diffusion, Spreadability, Zeta potential, Stability, span 40
DOI
https://doi.org/10.22270/jddt.v8i5-s.1989References
Shishodia S, Singh T, Chaturvedi MM. Modulation of transcription factors by curcumin, Advances in Experimental Medicine and Biology, 2007; 595:127-148.
Gupta SC, Patchva S, Koh W, Aggarwal BB. Discovery of curcumin, a component of golden spice, and its miraculous biological activities, Clinical and Experimental Pharmacology and Physiology, 2012; 39:283-99.
Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: Lessons learned from clinical trials, The AAPS Journal, 2013; 15:195-218.
Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian solid gold, Advances in Experimental Medicine and Biology, 2007; 595:1-75.
Aggarwal BB, Sung B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets, Trends in Pharmacological Sciences, 2009; 30:85-94.
Shanmugam MK, Rane G, Kanchi MM, Arfuso F, Chinnathambi A et al. The multifaceted role of curcumin in cancer prevention and treatment, Molecules, 2015; 20:2728-69.
Prasad S, Tyagi AK, Aggarwal BB. Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: The golden pigment from golden spice, Cancer Research and Treatment, 2014; 46:2-18.
Wang S, Su R, Nie S, Sun M, Zhang J, Wu D, Moustaid-Moussa N. Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals, The Journal of Nutritional Biochemistry, 2014; 25:363-376.
Fessi H, Puisieux F, Devissaquet JP et al. Nanocapsule formation by interfacial polymer deposition following solvent displacement, International Journal of Pharmaceutics, 1989; 55:R1–R4.
Kim TY, Kim DW, Chung JY et al. Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle formulated paclitaxel, in patients with advanced malignancies. Clinical Cancer Research, 2004; 10(11):3708–3716.
Ma Z, Shayeganpour A, Brocks DR, Lavasanifar A, Samuel J. High-performance liquid chromatography analysis of curcumin in rat plasma: application to pharmacokinetics of polymeric micellar formulation of curcumin, Biomedical Chromatography, 2007; 21(5):46-52.
Thangapazham RL, Puri A, Tele S, Blumenthal R, Maheshwari RK. Evaluation of a nanotechnology-based carrier for delivery of curcumin in prostate cancer cells, International Journal of Oncology, 2008; 32(5):1119–1123.
Sun Y, Lee CC, Hung WC et al. The bound states of amphipathic drugs in lipid bilayers: study of curcumin, Biophysical Journal, 2008; 95(5):2318–2324.
Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascu¬lar, pulmonary, metabolic, autoimmune and neoplastic diseases, The International Journal of Biochemistry & Cell Biology, 2009; 41(1):40-59.
Peltola S, Saarinen-Savolainen P, Kiesvaara J, Suhonen TM, Urtti A. Microemulsions for topical delivery of estradiol, International Journal of Pharmaceutics, 2003; 254(2):99-107.
Maestrelli F, Gonzalez-Rodriguez ML, Rabasco AM, Mura P. Effect of preparation technique on the properties of liposomes encapsulating ketoprofen-cyclodextrin complexes aimed for transdermal delivery, International Journal of Pharmaceutics, 2006; 312(1–2):53-60.
Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems, Advanced Drug Delivery Reviews, 2000; 45(1):89–121.
Chen H, Chang X, Weng T et al. A study of microemulsion systems for transdermal delivery of triptolide, Journal Control Release, 2004; 98(3):427-436.
Valenta C, Schultz K. Influence of carrageenan on the rheology and skin permeation of microemulsion formulations, Journal Control Release, 2004; 95(2):257–265.
Gulsen D, Chauhan A. Dispersion of microemulsion drops in HEMA hydrogel: a potential ophthalmic drug delivery vehicle, International Journal of Pharmaceutics, 2005; 292(1–2):95-117.
Buys LM, Elliott M. Osteoarthritis. In: DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey L. eds. Pharmacotherapy: A Pathophysiologic Approach. 9th ed. New York, NY: McGraw- Hill; 2014; 1437-1458.
Altman R, Asch E, Bloch G et al. Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee, Arthritis Rheum, 1986; 29: 1039-1049.
Hochberg MC, Altman RD, April KT et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee, Arthritis Care Research, 2012; 64:465-474.
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