FORMULATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF AN ANTI-MIGRAINE DRUG

  • S PADMA PRIYA College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India
  • AN Rajalakshmi College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India
  • P Ilaveni College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India
DOI https://doi.org/10.22270/jddt.v8i5.1943

Abstract

Objective: The objective of this research work is to develop and evaluate mucoadhesive microspheres of an anti-migraine drug for sustained release. Materials and Methods:  Mucoadhesive microspheres were prepared by emulsification method using Sodium alginate (SA), polyvinyl pyrrolidone (PVP) and Chitosan in the various drug-polymer ratios of 1:1, 1:2 and 1:3. Nine  formulations were formulated and  evaluated for  possible drug polymer interactions, percentage yield, micromeritic properties, particle size, drug content, drug entrapment efficiency, drug loading, swelling index, In-vitro wash off test, in vitro  drug release, surface morphology and release kinetics. Results: The results showed that no significant drug polymer interaction in FTIR studies. Among all the formulations SF3 containing sodium alginate showed 77.18% drug release in 6hrs. Conclusion: Amongst the developed mucoadhesive microspheres, SF3 formulation containing sodium alginate exhibited slow and sustained release in a controlled manner and it is a promising formulation for sustained release of Sumatriptan succinate.


Keywords: Mucoadhesive microspheres, Sodium alginate, polyvinyl pyrrolidone, Chitosan, sustained release.

Downloads

Download data is not yet available.

Author Biographies

S PADMA PRIYA, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India

College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India

AN Rajalakshmi, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India

College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India

P Ilaveni, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India

College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India

References

1. Boddupalli BM, Mohammed ZN, Nath RA, Banji D. Mucoadhesive drug delivery system: An overview. J Adv Pharm Technol Res 2010; 1:381-7.
2. Alagusundaram M, Chetty MS, Umashankari K, Badarinath AV, Lavanya C, Ramkanth S. Microspheres as a novel drug delivery system: A review. Int J Chem Tech Res 2009; 1(3):526-534.
3. Venkatesh Gavini, B. Ragini and K. Kaumudi. Mucoadhesive microspheres-a novel approach of drug targeting. Wjpps. 2014; 3(10):310-335.
4. A. Madhusudhan Reddy, J. Sindhura, B. Naga Lakshmi, A. Abhishekar Reedy, D. Navya Sri, M. Nireekshan Kumar and P. Srinivasa Babu. Formulation and evaluation of bilayered tablets of sumatriptan succinate by using hydrophilic polymers. Der Pharmacia Lettre, 2016; 8(5):189-206.
5. R Indira Prasanna, P Anitha, and C Madhusudhana Chetty. Formulation and evaluation of bucco-adhesive tablets of sumatriptan succinate. Int J Pharm Investig. 2011; 1(3):182–191.
6. Atul Kumar, Shubhendra Jha, Ravindra Rawal, P.S.Chauhan, Sheo Datta Maurya. Mucoadhesive Microspheres for Novel Drug Delivery System: A Review. Am. J. PharmTech Res. 2013; 3(4) ISSN: 2249-3387:195-213.
7. Baby H. Dandge, M H G Dehghan and Varsha M. Gaikwad. Preparation and characterization of mucoadhesive microparticles of sumatriptan succinate for intranasal delivery. Journal of Pharmacy Research 2009; 2(9):1536-1539.
8. Dada Khalandar K S, Yajaman Sudhakar, KN Jayaveera. Chitosan Based Nasal Microspheres of Sumatriptan: Formulation and In-Vitro Evaluation. Res. J. Pharma Bio & Chem Sciences. 2011; 2(3):489-498.
9. Engla G., Soni L., Dixit V. Sustained release delivery of repaglinide by biodegradable microspheres. Journal of Drug Delivery and Therapeutics, 2017; 7(7):77-80. https://doi.org/10.22270/jddt.v7i7.1593
10. Carol Mattson Porth, Glenn Matfin, Pathophysiology Concepts of Altered Health States Eighth edition. Lippincott Williams & Wilkins, 2009; 1251-1253.
11. Korsemeyer R.W et al. Mechanism of solute release from porous hydrophilic polymer. Int. J. Pharm. 1983; 15: 25-35.
Crossmark
Statistics
584 Views | 564 Downloads
How to Cite
1.
PADMA PRIYA S, Rajalakshmi A, Ilaveni P. FORMULATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF AN ANTI-MIGRAINE DRUG. JDDT [Internet]. 12Sep.2018 [cited 13May2024];8(5):465-74. Available from: https://jddtonline.info/index.php/jddt/article/view/1943
Issue
Vol 8 No 5 (2018): VOLUME 8, ISSUE 5, Sep-Oct 2018
Section
Research
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).