A PROMISING TECHNIQUE TO IMPROVE THE SOLUBILITY BY LIQUISOLID COMPACTION TECHNOLOGY
Abstract
About 60-70% of the drugs synthesized are poorly soluble and comes under BCS Class-II&IV. Now it is a challenging situation during the development of different dosage forms for pharmaceutical industries because solubility of the drug is the rate limiting step. Based on the solubility, the dissolution, bioavailability & therapeutic effect is dependent. To overcome this consequence a novel technique -Liquisolid compact is used by dissolving the poorly soluble drug in a non-volatile solvent that improves wettability & decreases the surface tension and ensures drug molecular dispersion in the formulation to increase the solubility of the drug. This admixture of drug loaded solution is blended with carrier adsorption & coating material (adsorption) that has free flowing and compressible powder properties.
Keywords:
BCS-Class II drug, Liquisolid Compact, Non-Volatile Liquid, Coating materialDOI
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