PHARMACOLOGICAL EVALUATION OF SOLANUM VIARUM DUNAL LEAVES EXTRACT FOR ANALGESIC AND ANTIPYRETIC ACTIVITIES
Abstract
The family Solanaceae consists of many plants, one of them is Solanum viarum Dunal. This plant contains chemical constituents like Solasodine which is found in many plants of Solanaceae family. The Solasodine have many medicinal properties and used as cardiotonic, antifungal, antispermatogenic, antiandrogenic, immunomodulatory, anticancer, anti-inflammatory, antinociceptive and as antipyretic. The study was carried out to ascertain analgesic and antipyretic activity of ethanolic extract of Solanum viarum Dunal leaves. The ethanolic extract of Solanum viarum Dunal leaves at 100 and 200mg/kg oral single dose treatment show a significant difference (p<0.0001) in reaction time in terms of analgesic activity before and after treatments comparable to standard drug Diclofenac (10mg/kg body weight) and also reduced the elevated body temperature induced by Brewer’s yeast. The extract also shows significant (p<0.0001) decrease in elevated body temperature at 100 and 200mg/kg comparable to standard drug Paracetamol (150mg/kg body weight).
Keywords Solanum viarum Dunal, Analgesic activity, Antipyretic activity.
DOI
https://doi.org/10.22270/jddt.v8i4.1812References
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