FORMULATION AND EVALUATION OF TASTE MASKED FAST DISSOLVING TABLET OF PRAZOSIN HYDROCHLORIDE
Abstract
The objective of this study was to control the elevated blood pressure in the patient with sudden episode of high blood pressure having markedly reduced function ability and restlessness. In such a case rapid onset of action is required. Prazosin Hydrochloride is drug with short biological half life. The purpose of study is to mask the bitter taste of drug and provide rapid onset of action. Inclusion complex of drug and β-Cyclodextrin can prepare by kneading method to mask the bitter taste of drug. 32 full factorial design was implemented, direct compression method were used to prepare tablet. F2 batch among all other batches showed disintegration time 55 sec with 98.56%drug release within 5min. thus it can be concluded the fast dissolving tablet can be formulated for antihypertensive drug.
Keyword: Prazosin Hydrochloride, β-Cyclodextrin, Kneading method, Inclusion Complex, Antihypertensive, Drug Release.
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References
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2. Ratnaparkhi M, “Formulation and Development of Taste Masked Orally Disintegrating Tablets of Perindopril Erbumine by Direct Compression Method†PAA; 3(5):1-10.
3. Rang HP, Dale MM, Ritter JM, Flower RJ, Henderson G. Rang and Dale’s Pharmacology. 7th ed. Published by Elsevier Churchill Livingstone; 2012.P. 199-202, 350.
4. Mulay M, Bankar V, “Preparation and Evaluation of Taste Masking Complex of Ciprofloxacin Hydrochloride by Using Inclusion Complexation Approach†WJPR, 2014; 3(5):1035-1045.
5. Ankita S, “Recent Technologies for The Taste Masking of Bitter Drugs†IJPPR.2012; 3(3):578-585.
6. Sharma D, Kumar D, Singh M, Sing G, Rathore M, “Taste Masking Technologies : A Novel Approach for the Improvement of Organoleptic Property of Pharmaceutical Active Substance†IRJP, 2012; 3(4):108-116.
7. Sharma YR. Elementary Organic Spectroscopy Principle and Chemical Application. 4th ed. New Delhi: S. Chand and Company Ltd Multicolor Edition; P.69-148.
8. Pavia DL, Lampman GM, Kriz GS. Introduction to Spectroscopy A Guide for Student of Organic Chemistry. 4th ed. Cennage Learning Pvt Ltd; 2007.P. 26-90.
9. Sudhir S, Tiwari A,â€Floating Microsphere of Prazosin Hydrochloride: Formulation, Characterization and in-vitro Evaluation†DPL, 2012; 4(4):1327-1338.
10. Kondi V, Allure R, “Optimization And Evaluation of Prazosin Hydrochloride Floating Microspheres Using Response Surface Methodology†JPBS, 2015; 10(3):58-68.
11. Bhise SB, Dias RJ, Dhawale SC, Mali KK. Laboratory Manual of Biopharmaceutics and Pharmacokinetics. Trinity Publishing House; 2010.P. 64-65.
12. The Indian Pharmacopoeia 2014. Government of India, Ministry of Health & Family Welfare, 7th ed. Vol-II. The Controller of Publication, New Delhi: P. 959-961.
13. Haritha B, “A Review on Evaluation of Tablets†JFSB, 2017; 1(1):1-5
14. Reddy P, Venkateswarlu P, “Design and Characterization of Fast Melt Tablet of Telmisartan†IJIPR, 2014; 5(1):357-363.
15. ICH Harmonised Tripartite Guidelines, International Conference on Harmonisation, Stability Testing of new drug substances and products Q1A(R2) and evaluation for stability data Q1E, Current step version. 6th February 2003.
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1.
Aher S, Saudagar R, Chaudhari D. FORMULATION AND EVALUATION OF TASTE MASKED FAST DISSOLVING TABLET OF PRAZOSIN HYDROCHLORIDE. JDDT [Internet]. 14Jul.2018 [cited 18Apr.2024];8(4):263-71. Available from: https://jddtonline.info/index.php/jddt/article/view/1785
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