DEVELOPMENT OF A KIND OF FLAVORING TABLETS FOR CHILDREN'S USE
Abstract
Objective: In this study, based on children's medication preferences, Synsepalum dulcificum and Siraitia grosvenorii as raw material were used to develop a flavoring medicine for children.
Methods: Synsepalum dulcificum and Siraitia grosvenorii as the raw material were applied to extract the Synsepalum dulcificum powder and Siraitia grosvenorii powder respectively, according to the orthogonal test design; the optimal proportion of flavoring powder was obtained. Low-substituted hydroxypropyl cellulose(L-HPC), polyvinylpolypyrrolidone(PVPP), sodium carboxymethyl starch(CMS-Na）, microcrystalline cellulose(MCC) were taken, according to the orthogonal test design the optimum proportion of auxiliary materials, then the flavoring tablets was prepared according to the preparation process.
Results: Through orthogonal test design, the optimum ratio of Synsepalum dulcificum: Siraitia grosvenorii was 1:3, and mixing them up in proportion; the optimum ratio of L-HPC: PVPP: CMS-Na: MCC was 10: 8: 3: 6, and mix them up in proportion. Equal amounts of sugar and salt were obtained by mass ratio of 1 to 1. Mixing 1/3 amount of flavoring powder with 3/4 amount of auxiliary materials, using 20% ethanol as a wetting agent, using the remaining sugar as a filler, and granulating. After the granules were dried and whole grain, add the remaining auxiliary materials and magnesium stearate were added, then the flavoring tablets were prepared.
Conclusion: The effects of this formula were prominent, which could effectively intervene the taste of children's medicine; solve the practical problems concerning taking medications in children.
Keywords: Synsepalum dulcificum; Siraitia grosvenorii; drug use in children; flavoring tablets
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Keywords:
Synsepalum dulcificum, Siraitia grosvenorii, drug use in children, flavoring tabletsDOI
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