DEVELOPMENT OF A KIND OF FLAVORING TABLETS FOR CHILDREN'S USE
Objective: In this study, based on children's medication preferences, Synsepalum dulcificum and Siraitia grosvenorii as raw material were used to develop a flavoring medicine for children.
Methods:Â Synsepalum dulcificum and Siraitia grosvenorii as the raw material were applied to extract the Synsepalum dulcificum powder and Siraitia grosvenorii powder respectively, according to the orthogonal test design; the optimal proportion of flavoring powder was obtained. Low-substituted hydroxypropyl cellulose(L-HPC), polyvinylpolypyrrolidone(PVPP), sodium carboxymethyl starch(CMS-Naï¼‰, microcrystalline cellulose(MCC) were taken, according to the orthogonal test design the optimum proportion of auxiliary materials, then the flavoring tablets was prepared according to the preparation process.
Results: Through orthogonal test design, the optimum ratio of Synsepalum dulcificum: Siraitia grosvenorii was 1:3, and mixing them up in proportion; the optimum ratio of L-HPC: PVPP: CMS-Na: MCC was 10: 8: 3: 6, and mix them up in proportion. Equal amounts of sugar and salt were obtained by mass ratio of 1 to 1. Mixing 1/3 amount of flavoring powder with 3/4 amount of auxiliary materials, using 20% ethanol as a wetting agent, using the remaining sugar as a filler, and granulating. After the granules were dried and whole grain, add the remaining auxiliary materials and magnesium stearate were added, then the flavoring tablets were prepared.
Conclusion: The effects of this formula were prominent, which could effectively intervene the taste of children's medicine; solve the practical problems concerning taking medications in children.
Keywords: Synsepalum dulcificum; Siraitia grosvenorii; drug use in children; flavoring tablets
2. Karaman R, Prodrugs for masking bitter taste of antibacterial drugs-a computational approach, J Mol Model, 2013; 19(6):2399-2412.
3. Sohi H, Sultana Y, Khar RK. Taste masking technologies in oral pharmaceuticals: Recent developments and approaches, Drug Dev Ind Pharm, 2004; 30(5):429-448.
4. Douroumis D. Practical approaches of taste masking technologies in oral solid forms. Expert Opin Drug Deliv, 2007; 4(4):417-26.
5. Ayenew Z, Puri V, Kumar L, et al.Trends in pharmaceutical taste masking technologies: A patent review, Recent Pat Drug Deliv Formul, 2009; 3(1):26-39.
6. DraÅ¡koviÄ‡ M, MedareviÄ‡ D, AleksiÄ‡ I, et al. In vitro and in vivo investigation of taste-masking effectiveness of Eudragit E PO as drug particle coating agent in orally disintegrating tablets. Drug Dev Ind Pharm, 2017; 43(5):723-731.
7. Shi DF, Wang YM, Chen S, et al. Protective effects and mechanisms of mogroside V on LPS-induced acute lung injury in mice. Pharmaceutical Biology, 2014; 52(6):729-734.
8. Qi XY, Chen WJ, LIU L G, et al. Effect of a Siraitia grosevenori extract containing mogrosides on the cellular immune system of type 1 diabetes mellitus mice. Molecular Nutrition & Food Research, 2006; 50(8):732-738.
9. Cheng M J, Lo W L, Huang L Y, et al. Isolation of a 2-oxetanone from the fruits of Synsepalum dulcificum. Nat. prod.res, 2010; 24(19):1850-1853.
10. Wong J M, Kern Mâ€™ Miracle fruit improves sweetness of a lowcalorie dessert without promoting subsequent energy compensation. Appetite, 2011; 56(1):163-166.
11. Brouwer J N, van der Wel H, Francke A, et al. Miraculin, the sweetnessinducing protein from miracle fruit. Nature, 1968; 220(10):373-374.
12. Girous E L, Henkin R I. Purification and some properties of miraculin, a glycop rotein from Synsepalum dulificum which provokes sweetness and blocks sourness. J Agr Food Chem, 1974; 22(4):595-601.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).