EXPLORING THE ANTI HYLOURINIDASE ACTIVITY OF GMELINA ARBOREA USING IN VITRO METHOD

  • Rupesh Kumar Pandey Research Scholar, Pacific University, Udaipur (Raj), India
  • Shiv Shankar Shukla Columbia Institute of Pharmacy, Raipur (C.G.), India

Abstract

Gmelina arborea is an important medicament in many anti arthritic drugs in ayurvedic system. Arthritis is complex disease which not only affects the joints but also affect the quality of life of patients.   Clinical data revealed that increase levels of hyaluronidase contribute significantly to cartilage degradation. We evaluated the cartilage protective action of the plant extract   (hydro alcoholic extract Gmelina arborea) by examining its effects on the activities of pure hyaluronidase. A simple spectrophotometric method was used to assay Hyaluronidase activity and to detect the potential of extracts. Hydro-alcoholic extracts of Gmelina arborea root and bark extract showed strong inhibition of hyaluronidase activity.

Keywords: Gmelina arborea, Arthritis, Hyaluronidase

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Author Biographies

Rupesh Kumar Pandey, Research Scholar, Pacific University, Udaipur (Raj), India
Research Scholar, Pacific University, Udaipur (Raj), India
Shiv Shankar Shukla, Columbia Institute of Pharmacy, Raipur (C.G.), India
Columbia Institute of Pharmacy, Raipur (C.G.), India

References

1. Colburn N, Review of Rheumatology. New York; London, Springer. 2012; 1-156. DOI 10.1007/978-1-84882-093-7.
2. Ebringer A. Rheumatoid Arthritis and Proteus. London; New York, Springer. 2012; X: 1-233.
3. Samy RP, Jayapal Manikandan and Mohammed Al Qahtani, Evaluation of Aromatic Plants and Compounds Used to Fight Multidrug Resistant Infections Evidence-Based Complementary and Alternative Medicine Volume 2013.
4. Micozzi MS, Fundamentals of Complementary and Alternative Medicine Churchill Livingstone. 2001.
5. Tung J.S., Mark G.E., Hollis GF., A microplate assay for hyaluronidase and hyaluronidase inhibitors. Anal Biochem. 1994; 15(1):149-152.
6. Venil, N.S., Kulkarni, A., Chandwaskar, R., Chondroprotective Potential of Fruit Extracts of Phyllanthus emblica in Osteoarthritis. Evid Based Complement Alternat Med. 2008; 5(3):329–335.
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1.
Pandey R, Shukla S. EXPLORING THE ANTI HYLOURINIDASE ACTIVITY OF GMELINA ARBOREA USING IN VITRO METHOD. JDDT [Internet]. 14May2018 [cited 5Aug.2021];8(3):75-7. Available from: https://jddtonline.info/index.php/jddt/article/view/1692