ADVANCEMENTS IN CONTROLLED RELEASE GASTRORETENTIVE DRUG DELIVERY SYSTEM: A REVIEW

Authors

  • Ami Makwana Department of Pharmaceutics, C.U.Shah College of pharmacy and Research Opp: IBP Petrol Pump, Surendranagar-Ahmedabad Highway, Wadhwan-363030
  • Krunal Sameja Department of Pharmaceutics, C.U.Shah College of pharmacy and Research Opp: IBP Petrol Pump, Surendranagar-Ahmedabad Highway, Wadhwan-363030
  • Hejal Parekh Department of Pharmaceutics, C.U.Shah College of pharmacy and Research Opp: IBP Petrol Pump, Surendranagar-Ahmedabad Highway, Wadhwan-363030
  • Yogi Pandya Arihant School of Pharmacy & Bio Research Institute, Uvarsad, gandhinagar

Abstract

Oral delivery of the drug is by far the most preferable route of drug delivery due to the ease of administration, patient compliance and flexibility in the formulations  but has a drawback of non-site specificity and short gastric resident time. In order to overcome the drawbacks of conventional oral drug delivery systems, several technical advancements have led to the development of gastro retentive  drug delivery system that could revolutionize method of medication and provide a number of therapeutic benefits. In order to understand various physiological difficulties to achieve gastric retention, we have summarized important factors controlling gastric retention. Afterwards, we have reviewed various gastroretentive approaches designed and developed until now, i.e. floating drug delivery system(FDDS), bio- or mucoadhesive system, expandable, unfoldable system, high density system, raft forming system, super porous hydrogel system and magnetic systems. Among these systems, FDDS have been most commonly used. Finally, advantages, disadvantages, evaluation, marketed preparation and future potential  of gastro retentive drug delivery systems were covered

DOI

https://doi.org/10.22270/jddt.v2i3.164

Published

2012-05-14
Statistics
Abstract Display: 2137
PDF Downloads: 2110

How to Cite

1.
Makwana A, Sameja K, Parekh H, Pandya Y. ADVANCEMENTS IN CONTROLLED RELEASE GASTRORETENTIVE DRUG DELIVERY SYSTEM: A REVIEW. J. Drug Delivery Ther. [Internet]. 2012 May 14 [cited 2025 Nov. 5];2(3). Available from: https://jddtonline.info/index.php/jddt/article/view/164

Issue

Vol. 2 No. 3 (2012): Volume 2, Issue 3, May-June 2012

Section

Review

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

How to Cite

1.
Makwana A, Sameja K, Parekh H, Pandya Y. ADVANCEMENTS IN CONTROLLED RELEASE GASTRORETENTIVE DRUG DELIVERY SYSTEM: A REVIEW. J. Drug Delivery Ther. [Internet]. 2012 May 14 [cited 2025 Nov. 5];2(3). Available from: https://jddtonline.info/index.php/jddt/article/view/164
Crossref
Scopus
Google Scholar
Europe PMC

Most read articles by the same author(s)