VALIDATED RP HPLC METHOD DEVELOPMENT FOR EXEMESTANE IN TABLET DOSAGE FORM
Abstract
The aim of this present work was to develop stability indicating LC method, which is selective, accurate, simple, precise, reliable, cost effective and rapid for the quantification of all possible degradants and determination of exemestane. In addition, to develop and validate Stability Indicating Method for the determination of impurities (degradation products) in exemestane API by RP-HPLC. Finally, validate the developed method as per ICH guidelines.
DOI
https://doi.org/10.22270/jddt.v7i7.1603References
Heftman E, Chromatography- Fundamentals & applications of Chromatography and Related differential migration methods, sixth ed., Elsevier, Amst. 69A, erdam, 2004, 53, 291.
Conners KA, A Textbook of Pharmaceutical Analysis, A Wiley- Interscience Publication, 1999, 3rd ed., 373-374.
Chatwal GR, Anand SK, Instrumental Methods of Chemical Analysis, Himalaya Publishing House, 2004, 2, 110.
Sethi PD, In; HPLC ‘High Performance Liquid Chromatography’, Quantitative Analysis of Pharmaceutical Formulations, CBS Publishers and Distributors, New Delhi, 2001, 3rd ed., 72, 116-120.
Snyder LR, Kirkland JJ, Glajch LJ, Practical HPLC Method Development, A Wiley-Interscience publication, New York, 1997, 2nd ed., 33:35.
Published
Abstract Display: 532 
PDF Downloads: 686 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.