FORMULATION DEVELOPMENT AND EVALUATION OF NOVEL DUAL-COMPARTMENT CAPSULE FOR STOMACH SPECIFIC DRUG DELIVERY
Abstract
The aim of the proposed research work was to develop a unique dual-compartment capsule dosage form of ciprofloxacin hydrochloride (CHL) which is well-known to have short elimination half-life and narrow absorption window. Formulated dual-compartment capsules were evaluated for its suitability for stomach specific drug delivery by employing different polymers such as Guar gum, Xanthan gum. Formulations were assessed for interaction studies, in vitro buoyancy, effect of polymer concentration on drug release and release kinetics. Experimental results demonstrated that natural polymers can be effectively exercised to formulate capsule dosage form for improved gastro retention and sustained drug release; which may be better and economic alternative for synthetic polymers.
DOI
https://doi.org/10.22270/jddt.v7i7.1597
Published
Abstract Display: 385 
PDF Downloads: 566 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.