DIALLYLDISULFIDE CONTAINING POLYMERIC NANOPARTICLES FOR SITE-SPECIFIC DELIVERY IN COLON CANCER
Abstract
Effective delivery of drugs to colon is a challenge, as the drug needs to be protected from gastrointestinal environment and should be released intact in colon. Present study is aimed to develop a site-specific nanoparticulate formulation containing herbal anti-cancer agent in treatment of colon cancer. The Diallyl disulfide nanoparticles (DADS-NPs) were prepared by nanoprecipetation method and optimized formulation was selected using Box-Behnken design (BBD). The particle size of NPs was found to be 108 nm. The encapsulation efficiency was found to be 77.24%. and in-vitro release data has revealed controlled and prolonged drug release upto 72h.
DOI
https://doi.org/10.22270/jddt.v7i7.1584References
Lu L, Chen G, Qiu Y, Li M, The development of a melt-extruded shellac carrier for the targeted delivery of probiotics to the colon, Sci Bull, 2016, 670–681.
Udompornmongkol P, Chiang B, Curcumin-loaded polymeric nanoparticles for enhanced anti-colorectal cancer applications, J Biomater Appl, 2015, 537-546.
Talluri SV, Kuppusamy G, Karri VVSR, Yamjala K, Multiple biological actions of curcumin in the management of diabetic foot ulcer complications: a systematic review, Artif Cells Nanomed Biotechnol, 2017, 474-488.
Published
Abstract Display: 377 
PDF Downloads: 516 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.