NOVEL DRY INJECTION FOR RECONSTITUTION OF ASPIRIN USING SOLID SOLUBILISERS
Abstract
The concept of mixed solvency is an emerging field which can serve as a milestone for solubility enhancement and therefore deserves an urgent attention of the scientific community to assess its efficiency and applicability. Mixed solvency concept suggested that each substance present on the earth whether solid, liquid or gas has solubilizing power. In mixed solvency concept each substance (gas, liquid or solid) is termed as solubilizer. Solubility enhancement by a single solubilizer in high concentration may raise the toxicity concern. Mixed solvency concept gives solution to this problem. Several solubilizers in small concentration in a blend may give desired solubility for a given drug and hence may be safe (non-toxic). In future, the industries shall use the solubilising properties of different additives for such purpose. The described research is one typical example where safe concentrations of additives have been used to prepare a dry injection for reconstitution of aspirin (a poorly water soluble drug)Â Â
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References
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