FORMULATION AND EVALUATION OF IVERMECTIN SOLID DISPERSION
Abstract
This study was aimed to formulate and evaluate solid dispersion containing ivermectin to improve solubility. Ivermectin is BCS (Biopharmaceutical classification system) class-II drug, which has high permeability and low water solubility (0.005mg/ml) which is responsible for its poor dissolution rate and ultimately leads to variable absorption. Solid dispersion with Gelucire (44/14) has the ability to improve dissolution of poor water soluble drugs. So, solid dispersion ivermectin with Gelucire 44/14 was prepared to enhance the solubility and was further evaluated for different parameters such as assay, wettability, DSC, FT-IR, dissolution study.
DOI
https://doi.org/10.22270/jddt.v7i7.1572References
Brig HK, Jain K, Jain R, A study of prevalence of intestinal worm infestation and efficacy of anthelminthic drug, Med J Armed Forces India, 2014, 70:144–148.
Dourmishev AL, Dourmishev LA, Schwartz RA, Ivermectin: Pharmacology and application in dermatology, J Dermatol, 2005, 44, 981–988.
Dalvi P, Gerange A. Ingale P, Solid dispersion: strategy to enhance solubility. Journal of Drug Delivery and Therapeutics, 2015; 5(2):20-28. doi:10.22270/jddt.v5i2.1060
Abbas IM, Mahmoud ED, Formulation of immediate release pellets containing famotidine solid dispersions, Saudi Pharm J, 2014, 22, 149–156.
Fox L, Anne M, Ivermectin: uses and impact 20 years on; Curr Opin Infect Dis, 2006, 19, 588-593.
Gupta MM, Patel MG, Patel NS, Kedawat M, Enhancement of dissolution rate of ibuprofen by preparing solid dispersion using different methods, IJPPS, 2011, 3, 204-206.
Published
Abstract Display: 3521 
PDF Downloads: 2465 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.